ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017146 Brca1 10090 - 11:101488764-101551955 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000017290 Brca1-001 101488764-101551879 protein_coding
  ENSMUST00000131460 Brca1-004 101512511-101522459 retained_intron
  ENSMUST00000142086 Brca1-002 101525507-101551955 nonsense_mediated_decay
  ENSMUST00000156843 Brca1-003 101496315-101508178 retained_intron
  ENSMUST00000188168 Brca1-006 101524207-101525206 processed_transcript
  ENSMUST00000190862 Brca1-005 101532083-101551582 protein_coding
  ENSMUST00000191198 Brca1-007 101524193-101524858 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000017290ENSMUST00000142086
Transcript ID C166 Tie2+ EC mES
ENSMUST00000017290 7.567±2.62 1.003±0.58 2.213±0.39
ENSMUST00000142086 N/A 0.106±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00061F CIL_00061F_0002 CGP
CIL_00040M CIL_00040M_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 IEA double-strand break repair via homologous recombination
GO:0000793 IDA condensed chromosome
GO:0000794 IDA condensed nuclear chromosome
GO:0003684 IDA damaged DNA binding
GO:0003723 ISO RNA binding
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005654 TAS nucleoplasm
GO:0005694 IDA chromosome
GO:0005737 IDA cytoplasm
GO:0005813 TAS centrosome
GO:0005886 IEA plasma membrane
GO:0006260 IMP DNA replication
GO:0006281 IEA DNA repair
GO:0006301 IEA postreplication repair
GO:0006302 IEA double-strand break repair
GO:0006310 IEA DNA recombination
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006633 IEA fatty acid biosynthetic process
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0007059 IEA chromosome segregation
GO:0007098 IGI centrosome cycle
GO:0008270 IEA zinc ion binding
GO:0008630 ISO intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009048 IDA dosage compensation by inactivation of X chromosome
GO:0010212 IEA response to ionizing radiation
GO:0010575 IEA positive regulation vascular endothelial growth factor production
GO:0010628 IEA positive regulation of gene expression
GO:0016874 IEA ligase activity
GO:0019899 IEA enzyme binding
GO:0030529 ISO ribonucleoprotein complex
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031436 ISS BRCA1-BARD1 complex
GO:0031572 IEA G2 DNA damage checkpoint
GO:0031625 IEA ubiquitin protein ligase binding
GO:0035066 IMP positive regulation of histone acetylation
GO:0035067 IMP negative regulation of histone acetylation
GO:0043009 IMP chordate embryonic development
GO:0043234 IEA protein complex
GO:0043627 IEA response to estrogen
GO:0044030 IMP regulation of DNA methylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045717 ISS negative regulation of fatty acid biosynthetic process
GO:0045739 IEA positive regulation of DNA repair
GO:0045766 IEA positive regulation of angiogenesis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0051298 TAS centrosome duplication
GO:0051571 IMP positive regulation of histone H3-K4 methylation
GO:0051572 IMP negative regulation of histone H3-K4 methylation
GO:0051573 IMP negative regulation of histone H3-K9 methylation
GO:0051574 IMP positive regulation of histone H3-K9 methylation
GO:0051865 ISS protein autoubiquitination
GO:0070512 IMP positive regulation of histone H4-K20 methylation
GO:0070531 IEA BRCA1-A complex
GO:0071158 IEA positive regulation of cell cycle arrest
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071681 IEA cellular response to indole-3-methanol
GO:0085020 ISS protein K6-linked ubiquitination
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000378 IEA negative regulation of reactive oxygen species metabolic process
GO:2000617 IMP positive regulation of histone H3-K9 acetylation
GO:2000620 IMP positive regulation of histone H4-K16 acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000012048 BRCA1 breast cancer 1, early onset protein_coding Homo_sapiens

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