ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021109 Hif1a 10090 + 12:73901375-73947530 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021530 Hif1a-001 73907904-73947530 protein_coding
  ENSMUST00000110461 Hif1a-003 73901375-73947530 protein_coding
  ENSMUST00000110464 Hif1a-002 73907904-73933076 protein_coding
  ENSMUST00000149740 Hif1a-004 73926602-73928532 retained_intron
  ENSMUST00000157041 Hif1a-005 73937670-73939881 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000021530ENSMUST00000110461
Transcript ID C166 Tie2+ EC mES
ENSMUST00000021530 41.188±4.86 35.948±3.70 13.214±1.26
ENSMUST00000110461 18.352±2.23 5.824±1.49 7.143±1.71

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00006H CIL_00006H_0002 CGP
CIL_0000S0 CIL_0000S0_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000989 IEA transcription factor binding transcription factor activity
GO:0001076 IPI RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IMP angiogenesis
GO:0001568 IMP blood vessel development
GO:0001666 ISS response to hypoxia
GO:0001755 IMP neural crest cell migration
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001892 IGI embryonic placenta development
GO:0001922 IMP B-1 B cell homeostasis
GO:0001944 IGI vasculature development
GO:0001947 IMP heart looping
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0002248 IMP connective tissue replacement involved in inflammatory response wound healing
GO:0003151 IMP outflow tract morphogenesis
GO:0003208 IMP cardiac ventricle morphogenesis
GO:0003677 IDA DNA binding
GO:0003700 ISO sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005667 IEA transcription factor complex
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0005829 ISS cytosol
GO:0006089 IMP lactate metabolic process
GO:0006110 IGI regulation of glycolytic process
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006366 IPI transcription from RNA polymerase II promoter
GO:0006879 IMP cellular iron ion homeostasis
GO:0007165 IEA signal transduction
GO:0007595 IMP lactation
GO:0008134 IEA transcription factor binding
GO:0008542 IMP visual learning
GO:0010468 IEA regulation of gene expression
GO:0010573 IEA vascular endothelial growth factor production
GO:0010575 ISS positive regulation vascular endothelial growth factor production
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0010870 IEA positive regulation of receptor biosynthetic process
GO:0014850 IMP response to muscle activity
GO:0019896 ISS axon transport of mitochondrion
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0021502 IMP neural fold elevation formation
GO:0021987 IMP cerebral cortex development
GO:0030154 IMP cell differentiation
GO:0030502 IMP negative regulation of bone mineralization
GO:0030949 IMP positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031514 IDA motile cilium
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032007 IMP negative regulation of TOR signaling
GO:0032364 IMP oxygen homeostasis
GO:0032909 IEA regulation of transforming growth factor beta2 production
GO:0032963 IMP collagen metabolic process
GO:0035035 ISS histone acetyltransferase binding
GO:0035162 IMP embryonic hemopoiesis
GO:0035257 IEA nuclear hormone receptor binding
GO:0035774 IMP positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 IMP regulation of cell proliferation
GO:0042541 IMP hemoglobin biosynthetic process
GO:0042593 IMP glucose homeostasis
GO:0042826 IPI histone deacetylase binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043619 IMP regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 IMP positive regulation of erythrocyte differentiation
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045926 IMP negative regulation of growth
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046716 IMP muscle cell cellular homeostasis
GO:0046886 IEA positive regulation of hormone biosynthetic process
GO:0046982 ISS protein heterodimerization activity
GO:0048514 IMP blood vessel morphogenesis
GO:0048546 IMP digestive tract morphogenesis
GO:0050790 IMP regulation of catalytic activity
GO:0051216 IMP cartilage development
GO:0051541 IMP elastin metabolic process
GO:0051879 IEA Hsp90 protein binding
GO:0060574 IMP intestinal epithelial cell maturation
GO:0061030 IMP epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298 IMP retina vasculature development in camera-type eye
GO:0061419 ISS positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243 IGI regulation of thymocyte apoptotic process
GO:0070244 IMP negative regulation of thymocyte apoptotic process
GO:0071347 IEA cellular response to interleukin-1
GO:0071456 ISS cellular response to hypoxia
GO:0071542 IGI dopaminergic neuron differentiation
GO:1903377 IEA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2001054 IMP negative regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006181 hif1aa protein_coding Danio_rerio
ENSDARG00000034293 hif1ab protein_coding Danio_rerio
ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein_coding Homo_sapiens

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