ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022607 Ptk2 10090 - 15:73205105-73423191 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000110036 Ptk2-201 73205105-73423191 protein_coding
  ENSMUST00000170939 Ptk2-202 73215557-73423191 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000110036
Transcript ID C166 Tie2+ EC mES
ENSMUST00000110036 14.565±6.60 22.461±2.79 21.256±7.57

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002XD CIL_0002XD_0002 CGP
CIL_0006FQ CIL_0006FQ_0003 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IDA microtubule cytoskeleton organization
GO:0001525 IMP angiogenesis
GO:0001568 IMP blood vessel development
GO:0001570 IMP vasculogenesis
GO:0001725 IEA stress fiber
GO:0001764 IDA neuron migration
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0003779 IEA actin binding
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IDA focal adhesion
GO:0006928 TAS cellular component movement
GO:0007172 IEA signal complex assembly
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 ISS regulation of cell shape
GO:0008432 IEA JUN kinase binding
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 IDA apical plasma membrane
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021955 IMP central nervous system neuron axonogenesis
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030027 IDA lamellipodium
GO:0030198 IMP extracellular matrix organization
GO:0030335 ISS positive regulation of cell migration
GO:0033628 ISS regulation of cell adhesion mediated by integrin
GO:0040023 IDA establishment of nucleus localization
GO:0042127 ISS regulation of cell proliferation
GO:0042169 IEA SH2 domain binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0043542 IMP endothelial cell migration
GO:0045667 ISS regulation of osteoblast differentiation
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046621 IGI negative regulation of organ growth
GO:0046777 IMP protein autophosphorylation
GO:0048013 ISS ephrin receptor signaling pathway
GO:0050771 IMP negative regulation of axonogenesis
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0051964 IMP negative regulation of synapse assembly
GO:0060396 IEA growth hormone receptor signaling pathway
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004672 ptk2ab protein_coding Danio_rerio
ENSG00000169398 PTK2 protein tyrosine kinase 2 protein_coding Homo_sapiens

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