ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024413 Npc1 10090 - 18:12189693-12236400 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025279 Npc1-001 12189693-12236400 protein_coding
  ENSMUST00000133112 Npc1-002 12217578-12236358 retained_intron
  ENSMUST00000144435 Npc1-005 12221846-12224087 processed_transcript
  ENSMUST00000145771 Npc1-006 12210384-12212554 processed_transcript
  ENSMUST00000149211 Npc1-003 12217994-12236326 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000025279ENSMUST00000145771
Transcript ID C166 Tie2+ EC mES
ENSMUST00000025279 7.498±0.86 6.069±2.68 13.536±4.70
ENSMUST00000145771 N/A 12.996±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005WY CIL_0005WY_0002 CGP
CIL_0005WX CIL_0005WX_0002 CGP
CIL_0005WW CIL_0005WW_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005635 ISS nuclear envelope
GO:0005764 IDA lysosome
GO:0005765 IEA lysosomal membrane
GO:0005768 IDA endosome
GO:0005783 ISS endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006486 IDA protein glycosylation
GO:0006897 IMP endocytosis
GO:0006914 ISO autophagy
GO:0007041 ISS lysosomal transport
GO:0007165 IEA signal transduction
GO:0007628 IGI adult walking behavior
GO:0008158 IEA hedgehog receptor activity
GO:0008203 IEA cholesterol metabolic process
GO:0008206 ISS bile acid metabolic process
GO:0015485 ISS cholesterol binding
GO:0016020 IDA membrane
GO:0016242 IGI negative regulation of macroautophagy
GO:0030301 ISS cholesterol transport
GO:0031579 IEA membrane raft organization
GO:0031982 IDA vesicle
GO:0033344 IMP cholesterol efflux
GO:0042493 IDA response to drug
GO:0042632 ISS cholesterol homeostasis
GO:0045121 IDA membrane raft
GO:0046686 IEA response to cadmium ion
GO:0048471 ISS perinuclear region of cytoplasm
GO:0060548 IEA negative regulation of cell death
GO:0070062 IEA extracellular vesicular exosome
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0071404 IDA cellular response to low-density lipoprotein particle stimulus
GO:0090150 IEA establishment of protein localization to membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017180 npc1 protein_coding Danio_rerio
ENSG00000141458 NPC1 Niemann-Pick disease, type C1 protein_coding Homo_sapiens

Loading