ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024563 Smad2 10090 + 18:76241580-76305731 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025453 Smad2-002 76261121-76305294 protein_coding
  ENSMUST00000091831 Smad2-003 76241701-76304730 protein_coding
  ENSMUST00000113930 Smad2-004 76262492-76302642 protein_coding
  ENSMUST00000165084 Smad2-007 76262492-76299837 protein_coding
  ENSMUST00000168423 Smad2-001 76241580-76305731 protein_coding
  ENSMUST00000171256 Smad2-005 76242046-76298450 protein_coding
  ENSMUST00000172198 Smad2-006 76242174-76299893 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000025453ENSMUST00000091831ENSMUST00000168423
Transcript ID C166 Tie2+ EC mES
ENSMUST00000025453 9.554±1.23 N/A N/A
ENSMUST00000091831 5.977±0.00 5.476±1.04 N/A
ENSMUST00000168423 12.940±3.20 9.121±2.94 7.411±0.67

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008EL CIL_0008EL_0002 VISTA
CIL_0008FI CIL_0008FI_0002 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0001657 IEP ureteric bud development
GO:0001701 IGI in utero embryonic development
GO:0001706 IMP endoderm formation
GO:0001707 IMP mesoderm formation
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003690 IDA double-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007182 ISO common-partner SMAD protein phosphorylation
GO:0007183 IEA SMAD protein complex assembly
GO:0007352 IEA zygotic specification of dorsal/ventral axis
GO:0007369 IGI gastrulation
GO:0007389 IGI pattern specification process
GO:0007492 IGI endoderm development
GO:0007507 IGI heart development
GO:0008134 IPI transcription factor binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009749 IGI response to glucose
GO:0009791 IGI post-embryonic development
GO:0009880 IGI embryonic pattern specification
GO:0009952 IMP anterior/posterior pattern specification
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0017015 IEA regulation of transforming growth factor beta receptor signaling pathway
GO:0019902 IEA phosphatase binding
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030073 IGI insulin secretion
GO:0030324 IGI lung development
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0030618 IEA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031016 IGI pancreas development
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032444 IEA activin responsive factor complex
GO:0032924 IEA activin receptor signaling pathway
GO:0033613 IEA activating transcription factor binding
GO:0034713 IEA type I transforming growth factor beta receptor binding
GO:0035265 IGI organ growth
GO:0035556 IDA intracellular signal transduction
GO:0038092 IEA nodal signaling pathway
GO:0043234 IEA protein complex
GO:0045165 IMP cell fate commitment
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA:IMP positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046872 IEA metal ion binding
GO:0048340 IMP paraxial mesoderm morphogenesis
GO:0048589 IGI developmental growth
GO:0048617 IGI embryonic foregut morphogenesis
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0051098 IDA regulation of binding
GO:0060021 IMP palate development
GO:0060039 IGI pericardium development
GO:0060395 IGI SMAD protein signal transduction
GO:0070410 IEA co-SMAD binding
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0070723 IEA response to cholesterol
GO:0071141 IEA SMAD protein complex
GO:0071144 IEA SMAD2-SMAD3 protein complex
GO:1900224 IEA positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006389 smad2 protein_coding Danio_rerio
ENSG00000175387 SMAD2 SMAD family member 2 protein_coding Homo_sapiens

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