ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026235 Epha4 10090 - 1:77367185-77515088 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027451 Epha4-201 77367185-77515088 protein_coding
  ENSMUST00000186930 Epha4-005 77401223-77515083 protein_coding
  ENSMUST00000187346 Epha4-006 77373613-77377607 protein_coding
  ENSMUST00000188797 Epha4-001 77373139-77515088 protein_coding
  ENSMUST00000188952 Epha4-002 77367189-77515079 nonsense_mediated_decay
  ENSMUST00000189934 Epha4-004 77396797-77515085 retained_intron
  ENSMUST00000190149 Epha4-003 77373631-77515079 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000027451ENSMUST00000188797ENSMUST00000188952ENSMUST00000190149
Transcript ID C166 Tie2+ EC mES
ENSMUST00000027451 1.216±0.00 1.903±0.78 2.700±0.17
ENSMUST00000188797 0.334±0.00 0.660±0.00 N/A
ENSMUST00000188952 3.055±2.55 2.587±1.07 N/A
ENSMUST00000190149 N/A 0.966±0.00 2.037±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006O4 CIL_0006O4_0002 CGP
CIL_0006XL CIL_0006XL_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 ISS protein kinase activity
GO:0005004 IMP GPI-linked ephrin receptor activity
GO:0005005 IDA transmembrane-ephrin receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 ISS cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0007155 IEA cell adhesion
GO:0007411 IMP axon guidance
GO:0007628 IMP adult walking behavior
GO:0008045 IMP motor neuron axon guidance
GO:0008347 IEA glial cell migration
GO:0009986 IEA cell surface
GO:0014069 IEA postsynaptic density
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0021957 IMP corticospinal tract morphogenesis
GO:0030054 IEA cell junction
GO:0030175 IEA filopodium
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0031594 IEA neuromuscular junction
GO:0031901 IDA early endosome membrane
GO:0032314 IDA regulation of Rac GTPase activity
GO:0032317 IMP regulation of Rap GTPase activity
GO:0032319 IEA regulation of Rho GTPase activity
GO:0042731 IEA PH domain binding
GO:0042802 IPI identical protein binding
GO:0042995 IEA cell projection
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043679 IEA axon terminus
GO:0044295 IEA axonal growth cone
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0046777 ISS protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048013 IEA ephrin receptor signaling pathway
GO:0048681 IMP negative regulation of axon regeneration
GO:0048710 IMP regulation of astrocyte differentiation
GO:0050770 IMP regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0061001 IMP regulation of dendritic spine morphogenesis
GO:0097155 IMP fasciculation of sensory neuron axon
GO:0097156 IMP fasciculation of motor neuron axon
GO:0097161 ISS DH domain binding
GO:2001108 ISS positive regulation of Rho guanyl-nucleotide exchange factor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010767 epha4l protein_coding Danio_rerio
ENSDARG00000054454 epha4a protein_coding Danio_rerio
ENSG00000116106 EPHA4 EPH receptor A4 protein_coding Homo_sapiens

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