ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039153 Runx2 10090 - 17:44495987-44814797 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000113568 Runx2-004 44608001-44814797 nonsense_mediated_decay
  ENSMUST00000113571 Runx2-201 44604001-44814797 protein_coding
  ENSMUST00000113572 Runx2-002 44604001-44736648 protein_coding
  ENSMUST00000159943 Runx2-003 44607531-44814581 protein_coding
  ENSMUST00000160199 Runx2-014 44639681-44734693 protein_coding
  ENSMUST00000160672 Runx2-006 44639777-44814264 nonsense_mediated_decay
  ENSMUST00000160673 Runx2-001 44607905-44814627 protein_coding
  ENSMUST00000161489 Runx2-005 44813906-44814627 retained_intron
  ENSMUST00000162130 Runx2-010 44608315-44735366 protein_coding
  ENSMUST00000162373 Runx2-012 44607819-44735634 protein_coding
  ENSMUST00000162629 Runx2-011 44607819-44814226 protein_coding
  ENSMUST00000162816 Runx2-008 44495987-44736176 nonsense_mediated_decay
  ENSMUST00000162878 Runx2-009 44606260-44735710 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000113571ENSMUST00000113572ENSMUST00000159943ENSMUST00000160199ENSMUST00000161489ENSMUST00000162373ENSMUST00000162816ENSMUST00000162878
Transcript ID C166 Tie2+ EC mES
ENSMUST00000113571 N/A 0.050±0.01 0.028±0.00
ENSMUST00000113572 0.372±0.14 N/A 0.024±0.00
ENSMUST00000159943 N/A 0.082±0.00 0.048±0.00
ENSMUST00000160199 N/A N/A 0.420±0.00
ENSMUST00000161489 N/A 1.164±0.06 N/A
ENSMUST00000162373 0.647±0.00 N/A 0.234±0.00
ENSMUST00000162816 N/A 0.089±0.00 0.080±0.00
ENSMUST00000162878 N/A 0.055±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007VA CIL_0007VA_0002 VISTA
CIL_0002LE CIL_0002LE_0002 CGP
CIL_00082L CIL_00082L_0002 VISTA
CIL_0007Z9 CIL_0007Z9_0002 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104 IEA RNA polymerase II transcription cofactor activity
GO:0001501 IMP skeletal system development
GO:0001649 IMP osteoblast differentiation
GO:0001958 IMP endochondral ossification
GO:0002051 IGI osteoblast fate commitment
GO:0002062 IGI chondrocyte differentiation
GO:0002063 IMP chondrocyte development
GO:0002076 IGI osteoblast development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008284 IMP positive regulation of cell proliferation
GO:0010628 IDA positive regulation of gene expression
GO:0016592 IEA mediator complex
GO:0019904 IPI protein domain specific binding
GO:0030217 IDA T cell differentiation
GO:0030278 IMP regulation of ossification
GO:0030509 IMP BMP signaling pathway
GO:0032332 IMP positive regulation of chondrocyte differentiation
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0040036 IMP regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042487 IMP regulation of odontogenesis of dentin-containing tooth
GO:0043425 IPI bHLH transcription factor binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045667 IDA regulation of osteoblast differentiation
GO:0045669 IGI positive regulation of osteoblast differentiation
GO:0045879 IMP negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048469 IGI cell maturation
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0048705 IMP skeletal system morphogenesis
GO:0048863 IDA stem cell differentiation
GO:0070491 IPI repressing transcription factor binding
GO:0071773 IMP cellular response to BMP stimulus
GO:1901522 IMP positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040261 runx2a protein_coding Danio_rerio
ENSDARG00000059233 runx2b protein_coding Danio_rerio
ENSG00000124813 RUNX2 runt-related transcription factor 2 protein_coding Homo_sapiens

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