ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000539097 HIF1A-201 ENSG00000100644 9606 + 14:61697622-61748259 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000989 IDA transcription factor binding transcription factor activity
GO:0001076 IEA RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IEA angiogenesis
GO:0001568 IEA blood vessel development
GO:0001666 IDA response to hypoxia
GO:0001755 IEA neural crest cell migration
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001892 IEA embryonic placenta development
GO:0001922 IEA B-1 B cell homeostasis
GO:0001938 IC positive regulation of endothelial cell proliferation
GO:0001944 IEA vasculature development
GO:0001947 IEA heart looping
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002248 ISS connective tissue replacement involved in inflammatory response wound healing
GO:0003151 IEA outflow tract morphogenesis
GO:0003208 IEA cardiac ventricle morphogenesis
GO:0003677 IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IPI transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006089 IEA lactate metabolic process
GO:0006110 IEA regulation of glycolytic process
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006879 IEA cellular iron ion homeostasis
GO:0007165 IEA:IMP signal transduction
GO:0007219 TAS Notch signaling pathway
GO:0007595 IEA lactation
GO:0008134 IPI transcription factor binding
GO:0008542 IEA visual learning
GO:0010468 IDA regulation of gene expression
GO:0010573 IDA vascular endothelial growth factor production
GO:0010575 IMP positive regulation vascular endothelial growth factor production
GO:0010634 ISS positive regulation of epithelial cell migration
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0014850 IEA response to muscle activity
GO:0019896 IMP axon transport of mitochondrion
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0021502 IEA neural fold elevation formation
GO:0021987 IEA cerebral cortex development
GO:0030154 IEA cell differentiation
GO:0030502 IEA negative regulation of bone mineralization
GO:0030949 IC positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031514 IEA motile cilium
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032007 IEA negative regulation of TOR signaling
GO:0032364 IDA oxygen homeostasis
GO:0032722 TAS positive regulation of chemokine production
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0032963 ISS collagen metabolic process
GO:0035035 IPI histone acetyltransferase binding
GO:0035162 IEA embryonic hemopoiesis
GO:0035257 IPI nuclear hormone receptor binding
GO:0035774 IEA positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 IEA regulation of cell proliferation
GO:0042541 IEA hemoglobin biosynthetic process
GO:0042593 IEA glucose homeostasis
GO:0042789 IC mRNA transcription from RNA polymerase II promoter
GO:0042826 IEA histone deacetylase binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043619 IDA regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 IC positive regulation of erythrocyte differentiation
GO:0045766 IC positive regulation of angiogenesis
GO:0045821 IC positive regulation of glycolytic process
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045926 IEA negative regulation of growth
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046716 IEA muscle cell cellular homeostasis
GO:0046886 IDA positive regulation of hormone biosynthetic process
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048514 IEA blood vessel morphogenesis
GO:0048546 IEA digestive tract morphogenesis
GO:0050790 IEA regulation of catalytic activity
GO:0051000 TAS positive regulation of nitric-oxide synthase activity
GO:0051216 IEA cartilage development
GO:0051541 ISS elastin metabolic process
GO:0051879 IDA Hsp90 protein binding
GO:0060574 IEA intestinal epithelial cell maturation
GO:0061030 IEA epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298 IEA retina vasculature development in camera-type eye
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 IMP positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101 IC positive regulation of chemokine-mediated signaling pathway
GO:0070243 IEA regulation of thymocyte apoptotic process
GO:0070244 IEA negative regulation of thymocyte apoptotic process
GO:0071347 IEP cellular response to interleukin-1
GO:0071456 IDA cellular response to hypoxia
GO:0071542 IEA dopaminergic neuron differentiation
GO:1903377 IDA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2001054 IEA negative regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110461 Hif1a-003 protein_coding Mus_musculus 0 3025
ENSMUST00000021530 Hif1a-001 protein_coding Mus_musculus 0 1960
ENSMUST00000110464 Hif1a-002 protein_coding Mus_musculus 0 976
ENSMUST00000157041 Hif1a-005 processed_transcript Mus_musculus 0 466
ENSMUST00000149740 Hif1a-004 retained_intron Mus_musculus 0 340

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