ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: FGR proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000000938 FGR 9606 - 1:27612064-27635277 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374003 FGR-002 27612669-27626569 protein_coding
  ENST00000374004 FGR-004 27612300-27624062 protein_coding
  ENST00000374005 FGR-001 27612064-27635277 protein_coding
  ENST00000399173 FGR-201 27612292-27626240 protein_coding
  ENST00000457296 FGR-007 27615514-27626135 protein_coding
  ENST00000468038 FGR-006 27623407-27626240 processed_transcript
  ENST00000475472 FGR-005 27623384-27635134 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000374003ENST00000374004ENST00000374005ENST00000399173ENST00000457296ENST00000468038ENST00000475472
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000374003 0.019±0.00 0.024±0.01 N/A N/A 0.026±0.02
ENST00000374004 0.107±0.00 0.037±0.02 4.430±0.00 N/A 0.106±0.18
ENST00000374005 N/A 0.035±0.00 N/A N/A 0.072±0.04
ENST00000399173 N/A N/A N/A N/A 0.061±0.04
ENST00000457296 N/A 0.048±0.03 N/A N/A 0.050±0.05
ENST00000468038 N/A 0.058±0.00 N/A N/A N/A
ENST00000475472 N/A N/A N/A 0.240±0.00 0.058±0.04

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008WN CIL_0008WN_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 ISS phosphotyrosine binding
GO:0002768 TAS immune response-regulating cell surface receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007229 ISS integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008360 ISS regulation of cell shape
GO:0009615 TAS response to virus
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 ISS actin cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 ISS protein kinase binding
GO:0030335 ISS positive regulation of cell migration
GO:0032587 ISS ruffle membrane
GO:0034987 ISS immunoglobulin receptor binding
GO:0034988 IDA Fc-gamma receptor I complex binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306 ISS positive regulation of mast cell degranulation
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 IEA:TAS innate immune response
GO:0045088 ISS regulation of innate immune response
GO:0045859 ISS regulation of protein kinase activity
GO:0046777 IDA protein autophosphorylation
GO:0050715 ISS positive regulation of cytokine secretion
GO:0050764 ISS regulation of phagocytosis
GO:0050830 ISS defense response to Gram-positive bacterium
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000028874 Fgr protein_coding Mus_musculus

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