ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000003436 TFPI 9606 - 2:187464230-187565760 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233156 TFPI-201 187464233-187554492 protein_coding
  ENST00000339091 TFPI-008 187478585-187554438 protein_coding
  ENST00000392365 TFPI-001 187464230-187513641 protein_coding
  ENST00000409676 TFPI-009 187478578-187554431 protein_coding
  ENST00000417013 TFPI-004 187496972-187554492 protein_coding
  ENST00000420747 TFPI-003 187497016-187554461 protein_coding
  ENST00000421427 TFPI-012 187496881-187565760 protein_coding
  ENST00000426055 TFPI-002 187466985-187554492 protein_coding
  ENST00000435414 TFPI-007 187467875-187513653 protein_coding
  ENST00000437725 TFPI-006 187496881-187554351 protein_coding
  ENST00000453013 TFPI-005 187496884-187554492 protein_coding
  ENST00000481132 TFPI-010 187467002-187519860 retained_intron
  ENST00000481389 TFPI-011 187483930-187496976 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000233156ENST00000392365ENST00000426055ENST00000453013ENST00000481132
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000233156 N/A 100.651±13.76 N/A N/A 45.473±28.98
ENST00000392365 19.636±7.92 7.869±7.30 166.130±0.00 68.378±0.00 57.295±77.91
ENST00000426055 33.765±13.36 12.116±10.04 N/A 94.690±0.00 127.778±123.09
ENST00000453013 N/A 15.931±0.03 N/A N/A N/A
ENST00000481132 N/A 0.331±0.03 N/A N/A 10.371±5.69

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00042L CIL_00042L_0002 CGP
CIL_00042K CIL_00042K_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004866 TAS endopeptidase inhibitor activity
GO:0004867 IEA serine-type endopeptidase inhibitor activity
GO:0005576 IEA:TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005783 IEA endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0007596 IEA:TAS blood coagulation
GO:0007598 TAS blood coagulation, extrinsic pathway
GO:0009986 IDA cell surface
GO:0010466 IEA negative regulation of peptidase activity
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0030414 IEA peptidase inhibitor activity
GO:0031225 IEA anchored component of membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034718 tfpia protein_coding Danio_rerio
ENSMUSG00000027082 Tfpi protein_coding Mus_musculus

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