ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: pyruvate dehydrogenase kinase, isozyme 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000004799 PDK4 9606 - 7:95583499-95596491 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000005178 PDK4-001 95583499-95596491 protein_coding
  ENST00000468445 PDK4-005 95586680-95587545 retained_intron
  ENST00000473301 PDK4-003 95594771-95596460 retained_intron
  ENST00000473796 PDK4-002 95584375-95592760 retained_intron
  ENST00000498190 PDK4-004 95587484-95589717 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000005178ENST00000473301ENST00000473796
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000005178 1.527±0.40 1.046±0.38 3.676±0.00 1.500±3.18
ENST00000473301 N/A N/A N/A 0.297±0.00
ENST00000473796 N/A 0.250±0.00 N/A 0.134±0.07

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008H4 CIL_0008H4_0001 VISTA
CIL_0006QC CIL_0006QC_0002 CGP
CIL_00053G CIL_00053G_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 IDA ATP binding
GO:0005739 TAS mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0006468 IEA protein phosphorylation
GO:0006885 ISS regulation of pH
GO:0008286 IMP insulin receptor signaling pathway
GO:0009267 IDA cellular response to starvation
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 ISS regulation of cellular ketone metabolic process
GO:0010906 IMP regulation of glucose metabolic process
GO:0042304 IMP regulation of fatty acid biosynthetic process
GO:0042593 ISS glucose homeostasis
GO:0042594 ISS response to starvation
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045124 IEA regulation of bone resorption
GO:0046320 ISS regulation of fatty acid oxidation
GO:0071398 IMP cellular response to fatty acid
GO:0072593 IMP reactive oxygen species metabolic process
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054848 pdk4 protein_coding Danio_rerio
ENSMUSG00000019577 Pdk4 protein_coding Mus_musculus

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