ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: dishevelled segment polarity protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000004975 DVL2 9606 - 17:7225341-7234545 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000005340 DVL2-001 7225341-7234545 protein_coding
  ENST00000571745 DVL2-017 7227149-7227827 retained_intron
  ENST00000572285 DVL2-003 7229287-7234223 retained_intron
  ENST00000573354 DVL2-014 7227863-7229267 retained_intron
  ENST00000574143 DVL2-010 7228007-7234061 protein_coding
  ENST00000574591 DVL2-013 7228600-7229406 retained_intron
  ENST00000574642 DVL2-007 7229153-7230391 processed_transcript
  ENST00000575086 DVL2-016 7226137-7229035 protein_coding
  ENST00000575458 DVL2-004 7225455-7234318 protein_coding
  ENST00000575756 DVL2-008 7227977-7234308 protein_coding
  ENST00000576285 DVL2-015 7227238-7228384 retained_intron
  ENST00000576439 DVL2-011 7229544-7230779 retained_intron
  ENST00000576840 DVL2-018 7226656-7228042 retained_intron
  ENST00000576949 DVL2-009 7230123-7234517 retained_intron
  ENST00000577154 DVL2-012 7228762-7229391 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000005340ENST00000572285ENST00000575458ENST00000575756ENST00000576285ENST00000576840ENST00000576949
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000005340 1.608±0.00 4.556±2.71 9.973±0.00 1.610±0.00 8.185±6.78
ENST00000572285 N/A N/A N/A N/A 0.232±0.00
ENST00000575458 N/A N/A N/A 1.863±0.00 2.412±1.65
ENST00000575756 N/A 4.343±0.85 N/A N/A 7.048±1.46
ENST00000576285 N/A N/A N/A N/A 2.143±1.02
ENST00000576840 N/A 3.445±0.54 N/A N/A 1.835±1.38
ENST00000576949 N/A N/A N/A N/A 0.464±0.06

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0003007 IBA heart morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0005109 IPI frizzled binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IBA plasma membrane
GO:0005938 IBA cell cortex
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007379 ISS segment specification
GO:0007507 ISS heart development
GO:0016055 IGI Wnt signaling pathway
GO:0019904 IEA protein domain specific binding
GO:0021535 IBA cell migration in hindbrain
GO:0022007 IEA convergent extension involved in neural plate elongation
GO:0030136 IBA clathrin-coated vesicle
GO:0031410 IDA cytoplasmic vesicle
GO:0034613 IEA cellular protein localization
GO:0035282 IEA segmentation
GO:0035329 TAS hippo signaling
GO:0035556 IEA intracellular signal transduction
GO:0035567 IMP non-canonical Wnt signaling pathway
GO:0042802 IPI identical protein binding
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043621 IEA protein self-association
GO:0044340 IDA canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045177 IBA apical part of cell
GO:0045334 TAS clathrin-coated endocytic vesicle
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060026 IBA convergent extension
GO:0060029 IEA convergent extension involved in organogenesis
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060071 IDA Wnt signaling pathway, planar cell polarity pathway
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:0090103 IBA cochlea morphogenesis
GO:0090179 IBA planar cell polarity pathway involved in neural tube closure
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056184 dvl2 protein_coding Danio_rerio
ENSMUSG00000020888 Dvl2 protein_coding Mus_musculus

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