ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020888 Dvl2 10090 + 11:70000595-70012301 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019362 Dvl2-001 70000595-70010111 protein_coding
  ENSMUST00000102575 Dvl2-006 70000617-70012301 nonsense_mediated_decay
  ENSMUST00000130820 Dvl2-004 70000821-70006961 retained_intron
  ENSMUST00000135422 Dvl2-002 70000835-70006013 retained_intron
  ENSMUST00000149477 Dvl2-003 70005458-70007473 retained_intron
  ENSMUST00000152732 Dvl2-005 70006980-70008069 retained_intron
  ENSMUST00000190940 Dvl2-201 70000617-70012301 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000019362ENSMUST00000190940
Transcript ID C166 Tie2+ EC mES
ENSMUST00000019362 26.426±1.14 2.510±0.00 18.082±3.52
ENSMUST00000190940 N/A N/A 7.007±2.60

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002ZV CIL_0002ZV_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001843 IMP neural tube closure
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0003007 IGI heart morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0005109 IBA frizzled binding
GO:0005515 IPI protein binding
GO:0005634 IMP nucleus
GO:0005737 ISO cytoplasm
GO:0005829 IDA cytosol
GO:0005856 NAS cytoskeleton
GO:0005886 IDA plasma membrane
GO:0005938 IBA cell cortex
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007379 IMP segment specification
GO:0007507 IMP heart development
GO:0016055 NAS Wnt signaling pathway
GO:0019904 IPI protein domain specific binding
GO:0021535 IBA cell migration in hindbrain
GO:0022007 IGI convergent extension involved in neural plate elongation
GO:0030136 IDA clathrin-coated vesicle
GO:0031410 ISO cytoplasmic vesicle
GO:0034613 IDA cellular protein localization
GO:0035282 IGI segmentation
GO:0035556 IEA intracellular signal transduction
GO:0035567 IEA non-canonical Wnt signaling pathway
GO:0042802 IPI identical protein binding
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043621 IDA protein self-association
GO:0044340 IEA canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045177 IDA apical part of cell
GO:0045893 IBA positive regulation of transcription, DNA-templated
GO:0046328 IBA regulation of JNK cascade
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060029 IGI convergent extension involved in organogenesis
GO:0060070 IGI canonical Wnt signaling pathway
GO:0060071 IGI Wnt signaling pathway, planar cell polarity pathway
GO:0061098 IGI positive regulation of protein tyrosine kinase activity
GO:0090103 IGI cochlea morphogenesis
GO:0090179 IGI planar cell polarity pathway involved in neural tube closure
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056184 dvl2 protein_coding Danio_rerio
ENSG00000004975 DVL2 dishevelled segment polarity protein 2 protein_coding Homo_sapiens

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