ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: nuclear receptor subfamily 1, group H, member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000012504 NR1H4 9606 + 12:100473708-100564413 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000188403 NR1H4-005 100503360-100563642 protein_coding
  ENST00000321046 NR1H4-004 100473916-100563511 nonsense_mediated_decay
  ENST00000392986 NR1H4-003 100473916-100563503 protein_coding
  ENST00000546380 NR1H4-008 100473955-100505766 protein_coding
  ENST00000548621 NR1H4-009 100493301-100505796 nonsense_mediated_decay
  ENST00000548884 NR1H4-001 100473708-100564413 protein_coding
  ENST00000549996 NR1H4-002 100473916-100563511 protein_coding
  ENST00000551184 NR1H4-007 100503453-100505824 protein_coding
  ENST00000551379 NR1H4-006 100503360-100563489 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHUVECENST00000188403ENST00000546380ENST00000548884ENST00000551379
Transcript ID BECs HAoEC HHSEC HUVEC
ENST00000188403 N/A N/A N/A 0.022±0.00
ENST00000546380 0.135±0.00 N/A N/A 0.069±0.00
ENST00000548884 N/A 0.004±0.00 0.629±0.00 0.009±0.00
ENST00000551379 N/A 0.044±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006BW CIL_0006BW_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001080 IC nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0001190 IDA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0003713 TAS transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0004872 IEA receptor activity
GO:0004879 ISS ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 IEA thyroid hormone receptor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005719 IDA nuclear euchromatin
GO:0006109 IEA regulation of carbohydrate metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0008206 IEA bile acid metabolic process
GO:0008270 IEA zinc ion binding
GO:0009749 IEA response to glucose
GO:0010467 TAS gene expression
GO:0016922 TAS ligand-dependent nuclear receptor binding
GO:0030522 ISS intracellular receptor signaling pathway
GO:0032052 ISS bile acid binding
GO:0032496 IEA response to lipopolysaccharide
GO:0034255 ISS regulation of urea metabolic process
GO:0038181 IDA bile acid receptor activity
GO:0038185 IDA intracellular bile acid receptor signaling pathway
GO:0042277 IEA peptide binding
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IDA:IEA sequence-specific DNA binding
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046965 IEA retinoid X receptor binding
GO:0048565 IEA digestive tract development
GO:0070857 TAS regulation of bile acid biosynthetic process
GO:0070858 IDA negative regulation of bile acid biosynthetic process
GO:0071417 ISS cellular response to organonitrogen compound
GO:0090181 TAS regulation of cholesterol metabolic process
GO:1902122 IDA chenodeoxycholic acid binding
GO:1903413 ISS cellular response to bile acid
GO:2000213 ISS positive regulation of glutamate metabolic process
GO:2001250 IEA positive regulation of ammonia assimilation cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057741 nr1h4 protein_coding Danio_rerio
ENSMUSG00000047638 Nr1h4 protein_coding Mus_musculus

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