ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: trio Rho guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000038382 TRIO 9606 + 5:14143702-14532128 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344135 TRIO-009 14488448-14510203 protein_coding
  ENST00000344204 TRIO-001 14143702-14510204 protein_coding
  ENST00000502490 TRIO-019 14388613-14397341 retained_intron
  ENST00000502816 TRIO-012 14143702-14290887 retained_intron
  ENST00000503399 TRIO-016 14492370-14496986 retained_intron
  ENST00000504606 TRIO-013 14290977-14297513 retained_intron
  ENST00000505971 TRIO-011 14143702-14287104 retained_intron
  ENST00000506611 TRIO-005 14474012-14477333 retained_intron
  ENST00000507714 TRIO-014 14419814-14420800 processed_transcript
  ENST00000508283 TRIO-021 14498516-14504674 retained_intron
  ENST00000508343 TRIO-017 14498139-14499181 retained_intron
  ENST00000508717 TRIO-022 14498516-14508333 retained_intron
  ENST00000509354 TRIO-020 14399024-14420186 retained_intron
  ENST00000509967 TRIO-008 14183798-14399400 protein_coding
  ENST00000510281 TRIO-007 14482417-14487789 retained_intron
  ENST00000510757 TRIO-023 14387343-14387950 retained_intron
  ENST00000511019 TRIO-006 14479321-14481796 retained_intron
  ENST00000512070 TRIO-010 14143837-14508676 nonsense_mediated_decay
  ENST00000512303 TRIO-018 14406214-14419904 retained_intron
  ENST00000512979 TRIO-015 14418783-14420021 processed_transcript
  ENST00000513206 TRIO-002 14290977-14532128 protein_coding
  ENST00000515144 TRIO-003 14293041-14489165 retained_intron
  ENST00000515710 TRIO-004 14440819-14466451 processed_transcript
  ENST00000620511 TRIO-201 14465589-14510201 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000344135ENST00000344204ENST00000509967ENST00000512070ENST00000620511
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000344135 4.938±2.04 N/A 9.111±0.00 N/A 16.584±9.51
ENST00000344204 N/A 9.445±3.10 N/A 18.801±0.00 12.249±7.46
ENST00000509967 N/A 14.395±1.12 N/A N/A 14.423±11.97
ENST00000512070 N/A 9.173±2.84 N/A 10.668±0.00 7.118±3.20
ENST00000620511 10.356±4.81 N/A N/A N/A 16.317±2.66

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0007185 TAS transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0019899 IEA enzyme binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 TAS positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000370 triob protein_coding Danio_rerio
ENSDARG00000019426 trioa protein_coding Danio_rerio
ENSMUSG00000022263 Trio protein_coding Mus_musculus

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