ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: sterol O-acyltransferase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000057252 SOAT1 9606 + 1:179293714-179358680 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000367619 SOAT1-001 179293802-179358680 protein_coding
  ENST00000426956 SOAT1-002 179294320-179341310 protein_coding
  ENST00000539888 SOAT1-201 179293714-179358677 protein_coding
  ENST00000540564 SOAT1-202 179293714-179358677 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000367619ENST00000426956ENST00000539888ENST00000540564
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000367619 0.418±0.00 5.036±1.07 N/A 4.774±0.00 3.293±1.99
ENST00000426956 N/A 10.116±2.79 N/A N/A 9.302±4.43
ENST00000539888 N/A N/A 3.144±0.00 N/A 1.169±0.47
ENST00000540564 N/A 1.625±0.75 N/A N/A 1.209±1.11

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000062 IDA fatty-acyl-CoA binding
GO:0004772 IMP sterol O-acyltransferase activity
GO:0005515 IPI protein binding
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0008203 IDA cholesterol metabolic process
GO:0010742 IMP macrophage derived foam cell differentiation
GO:0010878 IMP cholesterol storage
GO:0015485 IDA cholesterol binding
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0033344 IMP cholesterol efflux
GO:0034379 IMP very-low-density lipoprotein particle assembly
GO:0034435 IDA cholesterol esterification
GO:0034736 IDA cholesterol O-acyltransferase activity
GO:0042632 TAS cholesterol homeostasis
GO:0042986 IMP positive regulation of amyloid precursor protein biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062297 soat1 protein_coding Danio_rerio
ENSMUSG00000026600 Soat1 protein_coding Mus_musculus

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