ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065911 MTHFD2 9606 + 2:74198562-74217565 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000394053 MTHFD2-001 74198562-74217565 protein_coding
  ENST00000409601 MTHFD2-009 74198616-74215277 protein_coding
  ENST00000409804 MTHFD2-003 74198610-74215298 protein_coding
  ENST00000462026 MTHFD2-006 74206394-74210051 processed_transcript
  ENST00000470592 MTHFD2-007 74198613-74214741 nonsense_mediated_decay
  ENST00000477455 MTHFD2-004 74198615-74208721 processed_transcript
  ENST00000488086 MTHFD2-005 74198629-74206073 processed_transcript
  ENST00000489041 MTHFD2-008 74198615-74214605 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000394053ENST00000409601ENST00000409804ENST00000470592ENST00000477455ENST00000489041
Transcript ID HAoEC HUVEC
ENST00000394053 11.451±0.58 6.514±1.23
ENST00000409601 30.498±0.09 36.530±0.00
ENST00000409804 N/A 27.414±2.51
ENST00000470592 N/A 29.854±2.73
ENST00000477455 N/A 5.283±0.00
ENST00000489041 N/A 3.485±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002DN CIL_0002DN_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0003824 IEA catalytic activity
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IDA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IDA:IEA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 IDA extracellular space
GO:0005739 IBA mitochondrion
GO:0006730 IBA one-carbon metabolic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0042301 IDA phosphate ion binding
GO:0046653 IDA tetrahydrofolate metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000005667 Mthfd2 protein_coding Mus_musculus

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