ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Spi-1 proto-oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000066336 SPI1 9606 - 11:47354860-47378576 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000227163 SPI1-004 47354913-47378391 protein_coding
  ENST00000378538 SPI1-001 47354860-47378576 protein_coding
  ENST00000533030 SPI1-003 47355101-47378523 protein_coding
  ENST00000533968 SPI1-002 47358181-47378487 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000227163ENST00000378538ENST00000533030ENST00000533968
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000227163 0.071±0.00 0.060±0.04 12.395±0.00 N/A 0.032±0.01
ENST00000378538 N/A N/A 5.458±0.00 0.126±0.00 0.033±0.02
ENST00000533030 N/A 0.183±0.11 N/A N/A 0.165±0.09
ENST00000533968 N/A N/A N/A N/A 0.027±0.02

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002LM CIL_0002LM_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 ISS RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 IBA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 IDA core promoter binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0001205 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001944 IEA vasculature development
GO:0002320 IEA lymphoid progenitor cell differentiation
GO:0002573 IEA myeloid leukocyte differentiation
GO:0003677 IEA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003723 IEA RNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IBA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0030098 IEA lymphocyte differentiation
GO:0030218 IEA erythrocyte differentiation
GO:0030225 IEA macrophage differentiation
GO:0030851 IEA granulocyte differentiation
GO:0035019 IEA somatic stem cell maintenance
GO:0043011 IEA myeloid dendritic cell differentiation
GO:0043565 IEA sequence-specific DNA binding
GO:0043966 IMP histone H3 acetylation
GO:0044027 IDA hypermethylation of CpG island
GO:0045347 IEA negative regulation of MHC class II biosynthetic process
GO:0045646 IMP regulation of erythrocyte differentiation
GO:0045814 IDA negative regulation of gene expression, epigenetic
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051525 ISS NFAT protein binding
GO:0060033 IEA anatomical structure regression
GO:0090241 IMP negative regulation of histone H4 acetylation
GO:1902262 IEA apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000767 spi1b protein_coding Danio_rerio
ENSDARG00000067797 spi1a protein_coding Danio_rerio
ENSMUSG00000002111 Spi1 protein_coding Mus_musculus

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