ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: tumor necrosis factor receptor superfamily, member 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067182 TNFRSF1A 9606 - 12:6328757-6342114 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000162749 TNFRSF1A-001 6328757-6342114 protein_coding
  ENST00000366159 TNFRSF1A-004 6331240-6341848 protein_coding
  ENST00000437813 TNFRSF1A-012 6331872-6334244 processed_transcript
  ENST00000440083 TNFRSF1A-013 6333076-6342085 protein_coding
  ENST00000534885 TNFRSF1A-003 6328757-6342114 nonsense_mediated_decay
  ENST00000535038 TNFRSF1A-007 6330268-6331147 processed_transcript
  ENST00000535958 TNFRSF1A-009 6333737-6342035 processed_transcript
  ENST00000536194 TNFRSF1A-010 6333458-6342041 protein_coding
  ENST00000536717 TNFRSF1A-006 6329081-6331381 retained_intron
  ENST00000537842 TNFRSF1A-016 6329868-6333442 processed_transcript
  ENST00000538363 TNFRSF1A-008 6333920-6342004 processed_transcript
  ENST00000539372 TNFRSF1A-014 6330442-6341982 protein_coding
  ENST00000540022 TNFRSF1A-002 6329237-6342027 protein_coding
  ENST00000543048 TNFRSF1A-011 6333066-6342004 nonsense_mediated_decay
  ENST00000543359 TNFRSF1A-015 6329465-6333105 processed_transcript
  ENST00000543995 TNFRSF1A-005 6329145-6342004 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000162749ENST00000366159ENST00000440083ENST00000534885ENST00000539372ENST00000543359
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000162749 N/A 63.092±25.52 20.102±0.00 83.369±0.00 50.226±35.06
ENST00000366159 N/A N/A N/A N/A 2.556±0.00
ENST00000440083 N/A N/A N/A N/A 3.984±2.28
ENST00000534885 65.378±4.06 20.235±0.06 91.060±0.00 N/A N/A
ENST00000539372 N/A N/A N/A N/A 5.294±0.00
ENST00000543359 N/A N/A N/A N/A 30.241±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 IDA Golgi membrane
GO:0001666 IEA response to hypoxia
GO:0002020 IEA protease binding
GO:0005031 TAS tumor necrosis factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006693 IEA prostaglandin metabolic process
GO:0006915 TAS apoptotic process
GO:0006952 IEA defense response
GO:0006954 ISS inflammatory response
GO:0007165 IEA signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0008625 TAS extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009611 IEA response to wounding
GO:0009986 IEA cell surface
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0016032 IEA viral process
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0030424 IEA axon
GO:0032403 IEA protein complex binding
GO:0032496 IEA response to lipopolysaccharide
GO:0032715 IEA negative regulation of interleukin-6 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0033013 IEA tetrapyrrole metabolic process
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0042511 IMP positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 IEA defense response to bacterium
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043120 IEA tumor necrosis factor binding
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 IEA response to amino acid
GO:0043234 IEA protein complex
GO:0043235 IDA receptor complex
GO:0043279 IEA response to alkaloid
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045121 IDA membrane raft
GO:0045202 IEA synapse
GO:0045471 IEA response to ethanol
GO:0045766 IEA positive regulation of angiogenesis
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0050728 IMP negative regulation of inflammatory response
GO:0050729 ISS positive regulation of inflammatory response
GO:0051291 IEA protein heterooligomerization
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071392 IEA cellular response to estradiol stimulus
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018569 tnfrsf1a protein_coding Danio_rerio
ENSDARG00000090478 TMEM238 (1 of 2) protein_coding Danio_rerio
ENSMUSG00000030341 Tnfrsf1a protein_coding Mus_musculus

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