ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068831 RASGRP2 9606 - 11:64726911-64745456 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354024 RASGRP2-002 64726911-64745456 protein_coding
  ENST00000377485 RASGRP2-013 64741026-64744997 protein_coding
  ENST00000377486 RASGRP2-010 64740866-64744145 protein_coding
  ENST00000377487 RASGRP2-009 64740866-64744859 protein_coding
  ENST00000377489 RASGRP2-008 64740866-64745333 protein_coding
  ENST00000377494 RASGRP2-007 64726911-64743789 protein_coding
  ENST00000377497 RASGRP2-003 64726911-64744834 protein_coding
  ENST00000394428 RASGRP2-012 64740866-64742937 protein_coding
  ENST00000394429 RASGRP2-011 64740866-64742937 protein_coding
  ENST00000394430 RASGRP2-005 64740868-64744589 protein_coding
  ENST00000394432 RASGRP2-001 64726911-64744178 protein_coding
  ENST00000419843 RASGRP2-014 64742826-64744317 protein_coding
  ENST00000421556 RASGRP2-004 64726911-64744122 nonsense_mediated_decay
  ENST00000430645 RASGRP2-022 64741068-64744867 protein_coding
  ENST00000431822 RASGRP2-016 64739636-64744118 protein_coding
  ENST00000441258 RASGRP2-025 64740126-64744831 nonsense_mediated_decay
  ENST00000445445 RASGRP2-017 64739379-64742946 nonsense_mediated_decay
  ENST00000464324 RASGRP2-006 64726911-64740883 retained_intron
  ENST00000465852 RASGRP2-019 64735374-64737244 retained_intron
  ENST00000480443 RASGRP2-023 64742511-64744860 retained_intron
  ENST00000488071 RASGRP2-020 64726946-64735266 retained_intron
  ENST00000494001 RASGRP2-024 64730181-64737034 retained_intron
  ENST00000497441 RASGRP2-018 64735112-64737254 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000354024ENST00000377485ENST00000377487ENST00000377489ENST00000377494ENST00000377497ENST00000394428ENST00000394429ENST00000394430ENST00000394432ENST00000421556ENST00000430645ENST00000431822ENST00000441258ENST00000445445ENST00000464324ENST00000465852ENST00000480443ENST00000488071ENST00000497441
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000354024 N/A 0.857±0.00 N/A N/A 0.179±0.15
ENST00000377485 N/A 0.731±0.00 N/A N/A 0.550±0.45
ENST00000377487 N/A N/A N/A N/A 0.251±0.01
ENST00000377489 N/A 1.414±0.92 N/A N/A 0.427±0.15
ENST00000377494 0.103±0.00 N/A N/A N/A 0.070±0.01
ENST00000377497 N/A 0.992±0.70 26.204±0.00 N/A 0.123±0.09
ENST00000394428 N/A 2.208±1.74 N/A N/A 0.145±0.00
ENST00000394429 0.508±0.00 N/A N/A N/A N/A
ENST00000394430 0.052±0.00 0.051±0.02 N/A 0.398±0.00 0.197±0.18
ENST00000394432 N/A 0.869±0.22 N/A N/A 0.213±0.04
ENST00000421556 0.128±0.00 0.091±0.00 N/A 0.334±0.00 0.076±0.07
ENST00000430645 N/A 0.199±0.00 N/A N/A 0.144±0.00
ENST00000431822 N/A 0.028±0.00 N/A 1.341±0.00 0.143±0.00
ENST00000441258 N/A N/A N/A N/A 0.286±0.00
ENST00000445445 N/A 1.053±0.23 N/A N/A 0.377±0.27
ENST00000464324 N/A N/A N/A N/A 0.044±0.04
ENST00000465852 N/A 0.184±0.00 N/A N/A 0.032±0.00
ENST00000480443 N/A 0.074±0.00 N/A N/A 0.087±0.04
ENST00000488071 0.374±0.00 N/A N/A N/A 0.046±0.00
ENST00000497441 0.165±0.00 0.319±0.05 N/A N/A 0.199±0.07

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005J6 CIL_0005J6_0002 CGP
CIL_0005J1 CIL_0005J1_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0005085 IEA:IDA guanyl-nucleotide exchange factor activity
GO:0005509 NAS:IEA calcium ion binding
GO:0005622 IEA intracellular
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0007165 TAS signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007265 NAS Ras protein signal transduction
GO:0007596 TAS blood coagulation
GO:0008289 TAS lipid binding
GO:0019992 NAS diacylglycerol binding
GO:0030054 IEA cell junction
GO:0030168 TAS platelet activation
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043005 IEA neuron projection
GO:0043547 IEA positive regulation of GTPase activity
GO:0045202 IEA synapse
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0071277 IDA cellular response to calcium ion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062328 rasgrp2 protein_coding Danio_rerio
ENSMUSG00000032946 Rasgrp2 protein_coding Mus_musculus

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