ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: nemo-like kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087095 NLK 9606 + 17:28041737-28196381 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000407008 NLK-001 28042156-28196381 protein_coding
  ENST00000496808 NLK-002 28043030-28196381 nonsense_mediated_decay
  ENST00000582037 NLK-004 28042839-28048926 protein_coding
  ENST00000583517 NLK-003 28041737-28048324 processed_transcript
  ENST00000584188 NLK-005 28171233-28191172 processed_transcript
  ENST00000584878 NLK-006 28190941-28194985 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000407008ENST00000496808ENST00000582037
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000407008 0.485±0.00 6.795±3.20 2.686±0.00 11.516±0.00 7.793±4.20
ENST00000496808 N/A 4.042±0.99 N/A N/A 5.471±3.54
ENST00000582037 2.118±0.00 5.271±0.96 N/A N/A 5.549±2.04

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000287 ISS magnesium ion binding
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004707 IEA:ISS MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS:IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006468 ISS:IEA protein phosphorylation
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0008134 IPI transcription factor binding
GO:0016055 IEA Wnt signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0030178 ISS negative regulation of Wnt signaling pathway
GO:0031625 IPI ubiquitin protein ligase binding
GO:0033136 ISS serine phosphorylation of STAT3 protein
GO:0035556 ISS intracellular signal transduction
GO:0042169 ISS SH2 domain binding
GO:0046777 IEA protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028793 nlk2 protein_coding Danio_rerio
ENSMUSG00000017376 Nlk protein_coding Mus_musculus

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