ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: transcription factor AP-4 (activating enhancer binding protein 4)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000090447 TFAP4 9606 - 16:4257186-4273075 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000204517 TFAP4-001 4257186-4273075 protein_coding
  ENST00000572393 TFAP4-007 4261779-4263737 protein_coding
  ENST00000573476 TFAP4-006 4260455-4272831 nonsense_mediated_decay
  ENST00000574639 TFAP4-005 4258189-4272894 nonsense_mediated_decay
  ENST00000575300 TFAP4-002 4260498-4273075 retained_intron
  ENST00000575320 TFAP4-003 4257187-4267187 retained_intron
  ENST00000575672 TFAP4-004 4257186-4258798 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000204517ENST00000572393ENST00000573476ENST00000574639ENST00000575300ENST00000575320ENST00000575672
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000204517 2.972±0.00 1.218±0.87 1.142±0.00 1.377±0.00 1.477±0.92
ENST00000572393 1.888±0.00 3.248±1.47 N/A 2.886±0.00 1.330±0.37
ENST00000573476 N/A 1.584±0.69 N/A N/A 1.526±0.73
ENST00000574639 N/A 2.283±1.01 N/A 3.774±0.00 0.826±0.00
ENST00000575300 N/A 0.354±0.00 N/A N/A 0.466±0.01
ENST00000575320 N/A 0.114±0.04 N/A N/A 0.166±0.12
ENST00000575672 N/A 0.258±0.00 1.827±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00032P CIL_00032P_0001 CGP
CIL_0000WQ CIL_0000WQ_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0006978 IDA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008285 IMP negative regulation of cell proliferation
GO:0010629 IEA negative regulation of gene expression
GO:0017053 ISS transcriptional repressor complex
GO:0042803 IPI protein homodimerization activity
GO:0042826 IPI histone deacetylase binding
GO:0043065 IDA positive regulation of apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0043565 IDA sequence-specific DNA binding
GO:0043922 IDA negative regulation by host of viral transcription
GO:0043923 IDA positive regulation by host of viral transcription
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0070888 IDA E-box binding
GO:0071157 IMP negative regulation of cell cycle arrest
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:2001269 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000005718 Tfap4 protein_coding Mus_musculus

Loading