ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Mitogen-activated protein kinase kinase kinase MLT
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091436 ZAK 9606 + 2:173075435-173268010 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338983 ZAK-002 173075842-173227146 protein_coding
  ENST00000375213 ZAK-001 173075959-173268010 protein_coding
  ENST00000409176 ZAK-003 173075714-173266783 protein_coding
  ENST00000422149 ZAK-006 173090619-173187623 protein_coding
  ENST00000468408 ZAK-005 173075836-173191172 processed_transcript
  ENST00000476618 ZAK-004 173075868-173212825 retained_intron
  ENST00000480606 ZAK-007 173160010-173191177 processed_transcript
  ENST00000539448 ZAK-201 173075435-173222204 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000338983ENST00000375213ENST00000409176ENST00000468408ENST00000476618
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000338983 0.541±0.00 2.935±1.94 0.667±0.00 5.117±0.00 4.024±2.70
ENST00000375213 0.777±0.00 1.894±0.82 0.624±0.00 N/A 1.628±0.74
ENST00000409176 N/A 2.621±0.53 N/A N/A 1.531±0.70
ENST00000468408 N/A N/A N/A N/A 1.193±0.00
ENST00000476618 0.296±0.00 N/A N/A N/A 0.920±0.49

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003IJ CIL_0003IJ_0002 CGP
CIL_0008JV CIL_0008JV_0001 VISTA
CIL_0004KE CIL_0004KE_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000075 IDA cell cycle checkpoint
GO:0000077 IMP DNA damage checkpoint
GO:0000186 TAS activation of MAPKK activity
GO:0000287 IDA magnesium ion binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0006950 NAS response to stress
GO:0007010 IEA cytoskeleton organization
GO:0007050 IMP cell cycle arrest
GO:0007257 IDA activation of JUN kinase activity
GO:0008219 NAS cell death
GO:0008283 NAS cell proliferation
GO:0009314 IDA response to radiation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030154 NAS cell differentiation
GO:0035556 IDA intracellular signal transduction
GO:0043065 IDA positive regulation of apoptotic process
GO:0044822 IDA poly(A) RNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006978 zak protein_coding Danio_rerio
ENSDARG00000044615 zak protein_coding Danio_rerio
ENSMUSG00000004085 Zak protein_coding Mus_musculus

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