ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: proprotein convertase subtilisin/kexin type 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099139 PCSK5 9606 + 9:75890644-76362339 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376752 PCSK5-001 75890705-76195889 protein_coding
  ENST00000376767 PCSK5-003 75890670-76175562 protein_coding
  ENST00000424854 PCSK5-002 76095977-76358970 protein_coding
  ENST00000455778 PCSK5-004 76188639-76194960 protein_coding
  ENST00000545128 PCSK5-201 75890644-76362339 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000376752ENST00000376767ENST00000455778ENST00000545128
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000376752 0.158±0.03 1.844±0.76 0.281±0.00 0.849±0.55
ENST00000376767 0.412±0.17 0.964±0.38 0.141±0.00 0.478±0.22
ENST00000455778 0.729±0.00 N/A N/A 0.759±0.00
ENST00000545128 N/A N/A N/A 0.037±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IMP kidney development
GO:0002001 IEP renin secretion into blood stream
GO:0004175 IEA endopeptidase activity
GO:0004252 IDA:IEA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005615 IBA extracellular space
GO:0005794 ISS Golgi apparatus
GO:0005796 TAS Golgi lumen
GO:0006465 IDA signal peptide processing
GO:0006508 IEA proteolysis
GO:0007267 TAS cell-cell signaling
GO:0007507 ISS heart development
GO:0007566 ISS embryo implantation
GO:0008233 IDA:IEA peptidase activity
GO:0009952 IMP anterior/posterior pattern specification
GO:0016021 IEA integral component of membrane
GO:0016485 IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0019058 IEP viral life cycle
GO:0030141 ISS secretory granule
GO:0030323 ISS respiratory tube development
GO:0032455 TAS nerve growth factor processing
GO:0035108 ISS limb morphogenesis
GO:0042089 ISS cytokine biosynthetic process
GO:0042277 ISS peptide binding
GO:0043043 IDA peptide biosynthetic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048566 IMP embryonic digestive tract development
GO:0048706 IMP embryonic skeletal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060518 pcsk5b protein_coding Danio_rerio
ENSMUSG00000024713 Pcsk5 protein_coding Mus_musculus

Loading