ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: chromodomain helicase DNA binding protein 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100888 CHD8 9606 - 14:21385194-21456126 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000399982 CHD8-201 21385195-21431708 protein_coding
  ENST00000430710 CHD8-001 21385194-21437243 protein_coding
  ENST00000553283 CHD8-007 21429137-21437244 protein_coding
  ENST00000553622 CHD8-003 21431115-21437265 protein_coding
  ENST00000553651 CHD8-006 21431738-21437298 processed_transcript
  ENST00000553870 CHD8-012 21386011-21392788 protein_coding
  ENST00000554384 CHD8-010 21408323-21413006 retained_intron
  ENST00000555301 CHD8-011 21393671-21395014 retained_intron
  ENST00000555935 CHD8-004 21399606-21409890 protein_coding
  ENST00000555962 CHD8-008 21395024-21437230 processed_transcript
  ENST00000556833 CHD8-013 21431733-21456126 processed_transcript
  ENST00000557329 CHD8-009 21394109-21394767 retained_intron
  ENST00000557364 CHD8-002 21385486-21456080 protein_coding
  ENST00000557727 CHD8-005 21385199-21386344 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000399982ENST00000430710ENST00000555935ENST00000557364ENST00000557727
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000399982 N/A 3.695±1.49 N/A 3.504±0.00 1.883±0.85
ENST00000430710 N/A 6.064±1.73 N/A N/A 2.194±0.90
ENST00000555935 N/A N/A N/A N/A 2.174±1.15
ENST00000557364 N/A 5.165±2.22 N/A 3.991±0.00 3.200±1.69
ENST00000557727 18.392±3.63 N/A 33.235±0.00 N/A 7.677±0.45

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00078L CIL_00078L_0001 CGP
CIL_0003JD CIL_0003JD_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0002039 ISS p53 binding
GO:0003676 IEA nucleic acid binding
GO:0003677 IMP:IEA DNA binding
GO:0003678 IMP DNA helicase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0006200 IDA ATP catabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0008013 IDA beta-catenin binding
GO:0008094 IDA DNA-dependent ATPase activity
GO:0016787 IEA hydrolase activity
GO:0016817 IEA hydrolase activity, acting on acid anhydrides
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0032508 IMP DNA duplex unwinding
GO:0035064 IDA methylated histone binding
GO:0042393 ISS histone binding
GO:0043044 IMP ATP-dependent chromatin remodeling
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0045945 IMP positive regulation of transcription from RNA polymerase III promoter
GO:0060070 IDA canonical Wnt signaling pathway
GO:0070016 IEA armadillo repeat domain binding
GO:0071339 IDA MLL1 complex
GO:2000270 IEA negative regulation of fibroblast apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075543 chd8 protein_coding Danio_rerio
ENSMUSG00000053754 Chd8 protein_coding Mus_musculus

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