ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

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Gene Info
Description:	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000104365	IKBKB	9606	+	8:42271302-42332653	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000342222		IKBKB-001	42271334-42332450	nonsense_mediated_decay
	ENST00000416505		IKBKB-201	42271302-42332653	protein_coding
	ENST00000517388		IKBKB-020	42271390-42308932	nonsense_mediated_decay
	ENST00000517502		IKBKB-028	42317657-42320517	processed_transcript
	ENST00000517812		IKBKB-018	42271572-42305236	nonsense_mediated_decay
	ENST00000517890		IKBKB-003	42271316-42331132	nonsense_mediated_decay
	ENST00000517917		IKBKB-007	42271319-42319750	retained_intron
	ENST00000518647		IKBKB-010	42271390-42317224	retained_intron
	ENST00000518679		IKBKB-008	42271319-42331910	nonsense_mediated_decay
	ENST00000518983		IKBKB-019	42271370-42272429	protein_coding
	ENST00000519733		IKBKB-021	42271318-42308998	nonsense_mediated_decay
	ENST00000519735		IKBKB-004	42271318-42309765	protein_coding
	ENST00000519938		IKBKB-014	42320706-42331609	retained_intron
	ENST00000520201		IKBKB-009	42271389-42332455	retained_intron
	ENST00000520320		IKBKB-017	42271310-42306354	nonsense_mediated_decay
	ENST00000520655		IKBKB-012	42271463-42331909	nonsense_mediated_decay
	ENST00000520810		IKBKB-002	42271302-42331608	protein_coding
	ENST00000520835		IKBKB-006	42271318-42331064	protein_coding
	ENST00000521225		IKBKB-026	42325294-42329187	processed_transcript
	ENST00000521661		IKBKB-011	42271436-42329215	nonsense_mediated_decay
	ENST00000522103		IKBKB-016	42325610-42331909	retained_intron
	ENST00000522133		IKBKB-024	42322418-42326468	retained_intron
	ENST00000522147		IKBKB-022	42272083-42332037	protein_coding
	ENST00000522545		IKBKB-027	42314025-42316256	retained_intron
	ENST00000522785		IKBKB-023	42318608-42319870	processed_transcript
	ENST00000523018		IKBKB-025	42322441-42329314	retained_intron
	ENST00000523105		IKBKB-005	42271318-42322461	nonsense_mediated_decay
	ENST00000523517		IKBKB-013	42272083-42331121	nonsense_mediated_decay
	ENST00000523599		IKBKB-015	42324638-42329258	retained_intron

Expression Patterns Split around values. Cell Line Name Tissue Condition Heat Map Numeric Values Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC ENST00000342222 2.934±1.16 3.687±0.53 7.692±0.00 2.494±0.00 3.584±1.40 ENST00000416505 1.750±0.00 3.258±1.11 N/A N/A 2.330±0.45 ENST00000517890 N/A N/A N/A N/A 5.146±0.00 ENST00000518647 N/A N/A N/A N/A 1.798±1.11 ENST00000518679 3.345±0.88 N/A N/A N/A 3.050±0.09 ENST00000519938 N/A N/A N/A N/A 0.406±0.00 ENST00000520201 N/A 1.741±0.51 3.499±0.00 N/A 4.345±4.98 ENST00000520655 N/A N/A N/A N/A 0.266±0.00 ENST00000520810 N/A N/A N/A N/A 5.350±1.58 ENST00000520835 N/A 3.691±0.72 N/A N/A 3.045±0.65 ENST00000521661 N/A 3.911±0.05 N/A N/A 4.834±0.64 ENST00000522103 N/A N/A N/A N/A 4.187±0.00 ENST00000522147 15.035±0.00 N/A N/A N/A 10.652±1.50 ENST00000523517 N/A 4.379±0.88 N/A 7.074±0.00 4.748±0.94

Conserved Regions
Region ID	Sub-Region	Region Type
CIL_0007IG	CIL_0007IG_0002	CGP

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0001782	IEA	B cell homeostasis
GO:0002224	TAS	toll-like receptor signaling pathway
GO:0002755	TAS	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	TAS	MyD88-independent toll-like receptor signaling pathway
GO:0004672	IEA	protein kinase activity
GO:0004674	TAS	protein serine/threonine kinase activity
GO:0004713	IEA	protein tyrosine kinase activity
GO:0005515	IPI:IEA	protein binding
GO:0005524	IEA	ATP binding
GO:0005634	IEA	nucleus
GO:0005737	IDA	cytoplasm
GO:0005829	TAS	cytosol
GO:0006468	IEA	protein phosphorylation
GO:0006954	TAS	inflammatory response
GO:0007249	TAS	I-kappaB kinase/NF-kappaB signaling
GO:0007252	IEA	I-kappaB phosphorylation
GO:0008384	TAS:IEA	IkappaB kinase activity
GO:0008385	TAS	IkappaB kinase complex
GO:0009103	IEA	lipopolysaccharide biosynthetic process
GO:0009615	TAS	response to virus
GO:0009898	ISS	cytoplasmic side of plasma membrane
GO:0010765	IEA	positive regulation of sodium ion transport
GO:0016020	IEA	membrane
GO:0016772	IEA	transferase activity, transferring phosphorus-containing groups
GO:0016773	IEA	phosphotransferase activity, alcohol group as acceptor
GO:0019901	IPI	protein kinase binding
GO:0032481	TAS	positive regulation of type I interferon production
GO:0034134	TAS	toll-like receptor 2 signaling pathway
GO:0034138	TAS	toll-like receptor 3 signaling pathway
GO:0034142	TAS	toll-like receptor 4 signaling pathway
GO:0034146	TAS	toll-like receptor 5 signaling pathway
GO:0034162	TAS	toll-like receptor 9 signaling pathway
GO:0034166	TAS	toll-like receptor 10 signaling pathway
GO:0035631	ISS	CD40 receptor complex
GO:0035666	TAS	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	TAS	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	TAS	Fc-epsilon receptor signaling pathway
GO:0038123	TAS	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	TAS	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042501	IDA	serine phosphorylation of STAT protein
GO:0042803	IDA	protein homodimerization activity
GO:0043066	TAS	negative regulation of apoptotic process
GO:0043123	TAS	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	TAS	innate immune response
GO:0045893	NAS	positive regulation of transcription, DNA-templated
GO:0045944	IDA	positive regulation of transcription from RNA polymerase II promoter
GO:0046982	IDA	protein heterodimerization activity
GO:0048011	TAS	neurotrophin TRK receptor signaling pathway
GO:0050852	TAS	T cell receptor signaling pathway
GO:0051092	IDA	positive regulation of NF-kappaB transcription factor activity
GO:0070423	TAS	nucleotide-binding oligomerization domain containing signaling pathway
GO:0071356	IDA	cellular response to tumor necrosis factor
GO:0097110	IDA	scaffold protein binding
GO:2001259	IEA	positive regulation of cation channel activity

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000079123	ikbkb		protein_coding	Danio_rerio
ENSMUSG00000031537	Ikbkb		protein_coding	Mus_musculus

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I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
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Cache::write() - CORE/Cake/Cache/Cache.php, line 321
App::shutdown() - CORE/Cake/Core/App.php, line 899
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App::shutdown() - CORE/Cake/Core/App.php, line 899
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