ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104365 IKBKB 9606 + 8:42271302-42332653 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000342222 IKBKB-001 42271334-42332450 nonsense_mediated_decay
  ENST00000416505 IKBKB-201 42271302-42332653 protein_coding
  ENST00000517388 IKBKB-020 42271390-42308932 nonsense_mediated_decay
  ENST00000517502 IKBKB-028 42317657-42320517 processed_transcript
  ENST00000517812 IKBKB-018 42271572-42305236 nonsense_mediated_decay
  ENST00000517890 IKBKB-003 42271316-42331132 nonsense_mediated_decay
  ENST00000517917 IKBKB-007 42271319-42319750 retained_intron
  ENST00000518647 IKBKB-010 42271390-42317224 retained_intron
  ENST00000518679 IKBKB-008 42271319-42331910 nonsense_mediated_decay
  ENST00000518983 IKBKB-019 42271370-42272429 protein_coding
  ENST00000519733 IKBKB-021 42271318-42308998 nonsense_mediated_decay
  ENST00000519735 IKBKB-004 42271318-42309765 protein_coding
  ENST00000519938 IKBKB-014 42320706-42331609 retained_intron
  ENST00000520201 IKBKB-009 42271389-42332455 retained_intron
  ENST00000520320 IKBKB-017 42271310-42306354 nonsense_mediated_decay
  ENST00000520655 IKBKB-012 42271463-42331909 nonsense_mediated_decay
  ENST00000520810 IKBKB-002 42271302-42331608 protein_coding
  ENST00000520835 IKBKB-006 42271318-42331064 protein_coding
  ENST00000521225 IKBKB-026 42325294-42329187 processed_transcript
  ENST00000521661 IKBKB-011 42271436-42329215 nonsense_mediated_decay
  ENST00000522103 IKBKB-016 42325610-42331909 retained_intron
  ENST00000522133 IKBKB-024 42322418-42326468 retained_intron
  ENST00000522147 IKBKB-022 42272083-42332037 protein_coding
  ENST00000522545 IKBKB-027 42314025-42316256 retained_intron
  ENST00000522785 IKBKB-023 42318608-42319870 processed_transcript
  ENST00000523018 IKBKB-025 42322441-42329314 retained_intron
  ENST00000523105 IKBKB-005 42271318-42322461 nonsense_mediated_decay
  ENST00000523517 IKBKB-013 42272083-42331121 nonsense_mediated_decay
  ENST00000523599 IKBKB-015 42324638-42329258 retained_intron

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000342222ENST00000416505ENST00000517890ENST00000518647ENST00000518679ENST00000519938ENST00000520201ENST00000520655ENST00000520810ENST00000520835ENST00000521661ENST00000522103ENST00000522147ENST00000523517
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000342222 2.934±1.16 3.687±0.53 7.692±0.00 2.494±0.00 3.584±1.40
ENST00000416505 1.750±0.00 3.258±1.11 N/A N/A 2.330±0.45
ENST00000517890 N/A N/A N/A N/A 5.146±0.00
ENST00000518647 N/A N/A N/A N/A 1.798±1.11
ENST00000518679 3.345±0.88 N/A N/A N/A 3.050±0.09
ENST00000519938 N/A N/A N/A N/A 0.406±0.00
ENST00000520201 N/A 1.741±0.51 3.499±0.00 N/A 4.345±4.98
ENST00000520655 N/A N/A N/A N/A 0.266±0.00
ENST00000520810 N/A N/A N/A N/A 5.350±1.58
ENST00000520835 N/A 3.691±0.72 N/A N/A 3.045±0.65
ENST00000521661 N/A 3.911±0.05 N/A N/A 4.834±0.64
ENST00000522103 N/A N/A N/A N/A 4.187±0.00
ENST00000522147 15.035±0.00 N/A N/A N/A 10.652±1.50
ENST00000523517 N/A 4.379±0.88 N/A 7.074±0.00 4.748±0.94

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007IG CIL_0007IG_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001782 IEA B cell homeostasis
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006954 TAS inflammatory response
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007252 IEA I-kappaB phosphorylation
GO:0008384 TAS:IEA IkappaB kinase activity
GO:0008385 TAS IkappaB kinase complex
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0009615 TAS response to virus
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0010765 IEA positive regulation of sodium ion transport
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0019901 IPI protein kinase binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035631 ISS CD40 receptor complex
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042501 IDA serine phosphorylation of STAT protein
GO:0042803 IDA protein homodimerization activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 TAS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050852 TAS T cell receptor signaling pathway
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0097110 IDA scaffold protein binding
GO:2001259 IEA positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079123 ikbkb protein_coding Danio_rerio
ENSMUSG00000031537 Ikbkb protein_coding Mus_musculus

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