ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Janus kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105639 JAK3 9606 - 19:17824780-17848071 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000458235 JAK3-201 17824786-17848032 protein_coding
  ENST00000526008 JAK3-003 17838270-17848032 processed_transcript
  ENST00000527031 JAK3-004 17824780-17847991 retained_intron
  ENST00000527670 JAK3-005 17826152-17844447 protein_coding
  ENST00000528293 JAK3-002 17842435-17848071 retained_intron
  ENST00000528705 JAK3-006 17839424-17842525 retained_intron
  ENST00000534444 JAK3-001 17829788-17848017 protein_coding
  ENST00000613342 JAK3-202 17824786-17847991 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000458235ENST00000527031ENST00000527670ENST00000528293ENST00000534444
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000458235 N/A 0.332±0.11 N/A 2.258±0.00 1.645±1.36
ENST00000527031 1.539±1.12 N/A 2.744±0.00 N/A 0.359±0.00
ENST00000527670 N/A 0.118±0.00 N/A N/A 0.208±0.14
ENST00000528293 N/A N/A N/A N/A 0.021±0.00
ENST00000534444 N/A N/A N/A N/A 0.422±0.44

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002731 ISS negative regulation of dendritic cell cytokine production
GO:0004672 IEA protein kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006468 TAS:IEA protein phosphorylation
GO:0007167 ISS enzyme linked receptor protein signaling pathway
GO:0007260 TAS tyrosine phosphorylation of STAT protein
GO:0007262 TAS STAT protein import into nucleus
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019903 IPI protein phosphatase binding
GO:0030183 ISS B cell differentiation
GO:0032693 ISS negative regulation of interleukin-10 production
GO:0032695 ISS negative regulation of interleukin-12 production
GO:0035556 ISS:IEA intracellular signal transduction
GO:0035771 IDA interleukin-4-mediated signaling pathway
GO:0043029 ISS T cell homeostasis
GO:0045087 IEA innate immune response
GO:0045221 ISS negative regulation of FasL biosynthetic process
GO:0045626 ISS negative regulation of T-helper 1 cell differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050868 ISS negative regulation of T cell activation
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070232 ISS regulation of T cell apoptotic process
GO:0070244 ISS negative regulation of thymocyte apoptotic process
GO:0070669 TAS response to interleukin-2
GO:0070670 IDA response to interleukin-4
GO:0070672 TAS response to interleukin-15
GO:0071104 TAS response to interleukin-9
GO:2000670 IEA positive regulation of dendritic cell apoptotic process
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010252 jak3 protein_coding Danio_rerio
ENSMUSG00000031805 Jak3 protein_coding Mus_musculus

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