ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031805 Jak3 10090 + 8:71676296-71690575 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000051995 Jak3-001 71676296-71690575 protein_coding
  ENSMUST00000110012 Jak3-005 71677551-71688558 protein_coding
  ENSMUST00000110013 Jak3-004 71676296-71688556 protein_coding
  ENSMUST00000130624 Jak3-003 71678335-71690224 retained_intron
  ENSMUST00000133263 Jak3-002 71676552-71680306 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000051995ENSMUST00000110012ENSMUST00000110013ENSMUST00000130624
Transcript ID C166 Tie2+ EC mES
ENSMUST00000051995 1.545±0.60 13.680±2.43 4.834±1.82
ENSMUST00000110012 2.352±0.37 9.329±3.96 10.729±4.00
ENSMUST00000110013 0.834±0.00 N/A 4.214±0.30
ENSMUST00000130624 1.488±0.00 N/A N/A

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002731 IMP negative regulation of dendritic cell cytokine production
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005622 IC intracellular
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0007167 IDA enzyme linked receptor protein signaling pathway
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0016020 IEA membrane
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019903 IEA protein phosphatase binding
GO:0030183 IMP B cell differentiation
GO:0032693 IMP negative regulation of interleukin-10 production
GO:0032695 IMP negative regulation of interleukin-12 production
GO:0035556 IDA intracellular signal transduction
GO:0035771 IEA interleukin-4-mediated signaling pathway
GO:0042102 ISS positive regulation of T cell proliferation
GO:0042104 ISS positive regulation of activated T cell proliferation
GO:0042506 ISS tyrosine phosphorylation of Stat5 protein
GO:0043029 IMP T cell homeostasis
GO:0045087 IEA innate immune response
GO:0045221 IMP negative regulation of FasL biosynthetic process
GO:0045626 IMP negative regulation of T-helper 1 cell differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046777 ISS protein autophosphorylation
GO:0048535 TAS lymph node development
GO:0050778 ISS positive regulation of immune response
GO:0050868 IMP negative regulation of T cell activation
GO:0051928 ISS positive regulation of calcium ion transport
GO:0070232 IMP regulation of T cell apoptotic process
GO:0070244 IMP negative regulation of thymocyte apoptotic process
GO:0070669 TAS response to interleukin-2
GO:0070670 ISS response to interleukin-4
GO:0070672 TAS response to interleukin-15
GO:0071104 TAS response to interleukin-9
GO:2000670 IMP positive regulation of dendritic cell apoptotic process
GO:2001241 IMP positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010252 jak3 protein_coding Danio_rerio
ENSG00000105639 JAK3 Janus kinase 3 protein_coding Homo_sapiens

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