ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: growth factor receptor-bound protein 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106070 GRB10 9606 - 7:50590063-50793462 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000335866 GRB10-201 50590063-50793462 protein_coding
  ENST00000357271 GRB10-005 50592580-50732353 protein_coding
  ENST00000398810 GRB10-202 50590063-50705301 protein_coding
  ENST00000398812 GRB10-203 50590063-50732353 protein_coding
  ENST00000401949 GRB10-003 50592580-50782567 protein_coding
  ENST00000402497 GRB10-002 50592610-50793436 protein_coding
  ENST00000402578 GRB10-006 50590068-50727118 protein_coding
  ENST00000403097 GRB10-001 50590068-50792969 protein_coding
  ENST00000406641 GRB10-004 50592348-50756064 protein_coding
  ENST00000407526 GRB10-007 50592580-50756059 protein_coding
  ENST00000428711 GRB10-015 50617881-50626930 protein_coding
  ENST00000439044 GRB10-014 50674436-50793432 protein_coding
  ENST00000461886 GRB10-020 50592879-50595840 retained_intron
  ENST00000465602 GRB10-010 50727793-50747664 processed_transcript
  ENST00000467386 GRB10-012 50779457-50781471 processed_transcript
  ENST00000470992 GRB10-017 50755892-50781500 retained_intron
  ENST00000473696 GRB10-008 50595470-50607068 retained_intron
  ENST00000478162 GRB10-019 50779621-50781426 processed_transcript
  ENST00000482397 GRB10-009 50604909-50606413 retained_intron
  ENST00000483157 GRB10-011 50757116-50781401 processed_transcript
  ENST00000483819 GRB10-016 50755887-50782910 processed_transcript
  ENST00000490051 GRB10-018 50779718-50781430 retained_intron
  ENST00000492265 GRB10-013 50761658-50779570 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000335866ENST00000357271ENST00000398810ENST00000398812ENST00000402497ENST00000407526
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000335866 N/A 9.475±2.97 N/A 6.470±3.69
ENST00000357271 6.430±0.00 N/A N/A N/A
ENST00000398810 N/A 10.582±2.68 10.007±0.00 7.424±2.89
ENST00000398812 5.275±0.00 21.596±4.18 11.178±0.00 14.090±9.39
ENST00000402497 N/A N/A N/A 12.860±0.00
ENST00000407526 3.689±0.00 13.440±0.89 N/A 11.559±3.66

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008P3 CIL_0008P3_0001 VISTA
CIL_0008XT CIL_0008XT_0001 VISTA
CIL_0007SD CIL_0007SD_0001 VISTA
CIL_00089U CIL_00089U_0001 VISTA
CIL_0008KL CIL_0008KL_0001 VISTA
CIL_0004WV CIL_0004WV_0002 CGP
CIL_00072I CIL_00072I_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005070 IEA SH3/SH2 adaptor activity
GO:0005158 ISS insulin receptor binding
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007165 IEA signal transduction
GO:0008286 ISS insulin receptor signaling pathway
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 ISS response to insulin
GO:0042326 IEA negative regulation of phosphorylation
GO:0042327 ISS positive regulation of phosphorylation
GO:0045719 ISS negative regulation of glycogen biosynthetic process
GO:0046325 ISS negative regulation of glucose import
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0048009 IEA insulin-like growth factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002013 grb10a protein_coding Danio_rerio
ENSDARG00000035308 grb10b protein_coding Danio_rerio
ENSMUSG00000020176 Grb10 protein_coding Mus_musculus

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