ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: dedicator of cytokinesis 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107099 DOCK8 9606 + 9:214854-465259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000382329 DOCK8-005 366251-465255 protein_coding
  ENST00000382331 DOCK8-009 366229-405099 protein_coding
  ENST00000382341 DOCK8-002 273050-340620 retained_intron
  ENST00000432829 DOCK8-001 214865-465259 protein_coding
  ENST00000453981 DOCK8-201 273048-465259 protein_coding
  ENST00000454469 DOCK8-010 214868-340620 retained_intron
  ENST00000462618 DOCK8-016 463555-465247 processed_transcript
  ENST00000469197 DOCK8-008 214854-286636 nonsense_mediated_decay
  ENST00000469391 DOCK8-012 273070-464526 protein_coding
  ENST00000474772 DOCK8-007 311958-314466 processed_transcript
  ENST00000478380 DOCK8-011 273066-312941 retained_intron
  ENST00000479404 DOCK8-013 215171-289579 protein_coding
  ENST00000483757 DOCK8-004 273059-381387 nonsense_mediated_decay
  ENST00000487230 DOCK8-014 273050-304703 protein_coding
  ENST00000493666 DOCK8-015 420116-426953 processed_transcript
  ENST00000495184 DOCK8-006 273084-465241 retained_intron
  ENST00000524396 DOCK8-018 214865-340620 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000382329ENST00000382331ENST00000382341ENST00000432829ENST00000453981ENST00000462618ENST00000469197ENST00000469391ENST00000478380ENST00000495184ENST00000524396
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000382329 0.020±0.00 0.169±0.00 N/A N/A 0.141±0.03
ENST00000382331 0.081±0.00 N/A N/A N/A 0.244±0.00
ENST00000382341 0.072±0.00 N/A N/A N/A N/A
ENST00000432829 N/A 0.633±0.48 N/A 0.295±0.00 0.643±0.75
ENST00000453981 N/A 0.801±0.29 N/A N/A 0.318±0.24
ENST00000462618 N/A N/A 2.995±0.00 N/A N/A
ENST00000469197 N/A N/A N/A N/A 0.405±0.00
ENST00000469391 N/A 0.115±0.00 N/A N/A 0.141±0.08
ENST00000478380 N/A 0.200±0.00 N/A N/A N/A
ENST00000495184 0.024±0.00 0.107±0.00 0.112±0.00 N/A 0.111±0.06
ENST00000524396 0.120±0.00 0.331±0.00 N/A N/A 0.346±0.07

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0009AF CIL_0009AF_0001 VISTA
CIL_0000VS CIL_0000VS_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001771 IEA immunological synapse formation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0016020 IDA membrane
GO:0031252 IEA cell leading edge
GO:0036336 IEA dendritic cell migration
GO:0043547 IEA positive regulation of GTPase activity
GO:0061485 IMP memory T cell proliferation
GO:0070233 IEA negative regulation of T cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055225 dock8 protein_coding Danio_rerio
ENSMUSG00000052085 Dock8 protein_coding Mus_musculus

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