ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: growth hormone receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000112964 GHR 9606 + 5:42423777-42721878 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000230882 GHR-001 42423777-42721877 protein_coding
  ENST00000357703 GHR-201 42565864-42721878 protein_coding
  ENST00000505006 GHR-004 42514147-42619821 processed_transcript
  ENST00000511135 GHR-002 42565856-42719791 nonsense_mediated_decay
  ENST00000513625 GHR-005 42713867-42718814 processed_transcript
  ENST00000513671 GHR-003 42424518-42659364 nonsense_mediated_decay
  ENST00000537449 GHR-202 42550080-42721878 protein_coding
  ENST00000612382 GHR-203 42548213-42721878 protein_coding
  ENST00000612626 GHR-204 42549556-42721878 protein_coding
  ENST00000615111 GHR-205 42424452-42721878 protein_coding
  ENST00000618088 GHR-206 42548043-42721878 protein_coding
  ENST00000620156 GHR-207 42424452-42721878 protein_coding
  ENST00000622294 GHR-208 42565864-42721878 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000230882ENST00000357703ENST00000511135ENST00000513625ENST00000537449ENST00000615111ENST00000622294
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000230882 N/A 0.287±0.07 0.767±0.00 0.110±0.08
ENST00000357703 0.057±0.02 0.535±0.18 N/A 0.090±0.08
ENST00000511135 N/A 0.298±0.11 N/A 0.045±0.02
ENST00000513625 N/A 0.660±0.09 N/A 0.319±0.17
ENST00000537449 N/A 0.164±0.05 2.218±0.00 0.044±0.00
ENST00000615111 N/A 0.098±0.00 N/A 0.019±0.00
ENST00000622294 0.081±0.02 0.242±0.11 N/A 0.063±0.08

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 ISS activation of MAPK activity
GO:0000255 ISS allantoin metabolic process
GO:0004896 IEA cytokine receptor activity
GO:0004903 IEA growth hormone receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IMP extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006101 ISS citrate metabolic process
GO:0006103 ISS 2-oxoglutarate metabolic process
GO:0006105 ISS succinate metabolic process
GO:0006107 ISS oxaloacetate metabolic process
GO:0006549 ISS isoleucine metabolic process
GO:0006573 ISS valine metabolic process
GO:0006600 ISS creatine metabolic process
GO:0006631 ISS fatty acid metabolic process
GO:0006897 IEA endocytosis
GO:0007259 ISS JAK-STAT cascade
GO:0009725 IEA response to hormone
GO:0009755 IEA hormone-mediated signaling pathway
GO:0009986 IDA cell surface
GO:0016021 IDA integral component of membrane
GO:0017046 IPI peptide hormone binding
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019530 ISS taurine metabolic process
GO:0019838 IPI growth factor binding
GO:0019898 IEA extrinsic component of membrane
GO:0019901 ISS protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0031623 IDA receptor internalization
GO:0032094 IEA response to food
GO:0032355 IDA response to estradiol
GO:0032869 IEA cellular response to insulin stimulus
GO:0032870 IMP cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0040014 ISS regulation of multicellular organism growth
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042169 IEA SH2 domain binding
GO:0042517 ISS positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523 ISS positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042803 IDA protein homodimerization activity
GO:0042976 IEA activation of Janus kinase activity
GO:0042977 ISS activation of JAK2 kinase activity
GO:0043025 IEA neuronal cell body
GO:0043235 IDA receptor complex
GO:0043278 IEA response to morphine
GO:0043434 IEA response to peptide hormone
GO:0044236 IMP multicellular organismal metabolic process
GO:0045597 IEA positive regulation of cell differentiation
GO:0046427 IEA positive regulation of JAK-STAT cascade
GO:0046449 ISS creatinine metabolic process
GO:0046898 IDA response to cycloheximide
GO:0048009 IMP insulin-like growth factor receptor signaling pathway
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0051384 IEA response to glucocorticoid
GO:0060351 IEA cartilage development involved in endochondral bone morphogenesis
GO:0060396 IMP growth hormone receptor signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070064 ISS proline-rich region binding
GO:0070195 IDA growth hormone receptor complex
GO:0070555 IEA response to interleukin-1
GO:1901215 IEA negative regulation of neuron death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007671 ghrb protein_coding Danio_rerio
ENSDARG00000054771 ghra protein_coding Danio_rerio
ENSMUSG00000055737 Ghr protein_coding Mus_musculus

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