ANGIOGENES

ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info
Description:	IL2-inducible T-cell kinase
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000113263	ITK	9606	+	5:157142933-157255191	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000422843		ITK-001	157180826-157255191	protein_coding
	ENST00000517779		ITK-007	157180867-157214210	nonsense_mediated_decay
	ENST00000519402		ITK-002	157180843-157255099	retained_intron
	ENST00000519749		ITK-005	157241591-157255185	processed_transcript
	ENST00000519759		ITK-009	157222749-157240131	retained_intron
	ENST00000520173		ITK-010	157240093-157244275	retained_intron
	ENST00000520555		ITK-006	157180840-157211511	retained_intron
	ENST00000521769		ITK-008	157142933-157222963	protein_coding
	ENST00000522616		ITK-003	157180837-157195907	processed_transcript
	ENST00000523926		ITK-011	157244891-157245976	retained_intron

Expression Patterns

No expression data.

Conserved Regions
Region ID	Sub-Region	Region Type
CIL_00094M	CIL_00094M_0001	VISTA
CIL_00023X	CIL_00023X_0001	CGP

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0001816	ISS	cytokine production
GO:0001865	IEA	NK T cell differentiation
GO:0002250	ISS	adaptive immune response
GO:0004672	IEA	protein kinase activity
GO:0004713	IEA	protein tyrosine kinase activity
GO:0004715	IDA	non-membrane spanning protein tyrosine kinase activity
GO:0005515	IPI:IEA	protein binding
GO:0005524	IEA	ATP binding
GO:0005829	TAS	cytosol
GO:0005911	IEA	cell-cell junction
GO:0006468	IEA	protein phosphorylation
GO:0006968	TAS	cellular defense response
GO:0007165	TAS	signal transduction
GO:0007202	ISS	activation of phospholipase C activity
GO:0016772	IEA	transferase activity, transferring phosphorus-containing groups
GO:0018108	IEA	peptidyl-tyrosine phosphorylation
GO:0032609	IEA	interferon-gamma production
GO:0032633	IEA	interleukin-4 production
GO:0035556	IEA	intracellular signal transduction
GO:0038095	TAS	Fc-epsilon receptor signaling pathway
GO:0042110	TAS	T cell activation
GO:0045087	TAS	innate immune response
GO:0046872	IEA	metal ion binding
GO:0050852	ISS	T cell receptor signaling pathway

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000017565	itk		protein_coding	Danio_rerio
ENSMUSG00000020395	Itk		protein_coding	Mus_musculus

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