ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: phosphodiesterase 4D, cAMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113448 PDE4D 9606 - 5:58969038-60522120 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309641 PDE4D-013 58974921-59768509 nonsense_mediated_decay
  ENST00000317118 PDE4D-020 58974018-58999932 protein_coding
  ENST00000340635 PDE4D-001 58969038-59893798 protein_coding
  ENST00000358923 PDE4D-019 58973772-59039512 protein_coding
  ENST00000360047 PDE4D-014 58973688-59586499 protein_coding
  ENST00000405053 PDE4D-002 58993425-59893285 processed_transcript
  ENST00000405755 PDE4D-015 58974563-59356975 protein_coding
  ENST00000502484 PDE4D-003 58974657-60488076 protein_coding
  ENST00000502575 PDE4D-011 59157066-59768636 protein_coding
  ENST00000503258 PDE4D-016 58974561-59276119 protein_coding
  ENST00000504624 PDE4D-023 59988235-59988704 processed_transcript
  ENST00000505453 PDE4D-017 58974921-59586393 protein_coding
  ENST00000505507 PDE4D-009 59988517-60488063 protein_coding
  ENST00000506024 PDE4D-008 59988321-60448707 retained_intron
  ENST00000506510 PDE4D-006 59988361-60522120 retained_intron
  ENST00000507116 PDE4D-012 58973688-59768645 protein_coding
  ENST00000509355 PDE4D-004 59988159-60488098 retained_intron
  ENST00000509368 PDE4D-005 59986398-60262559 nonsense_mediated_decay
  ENST00000511382 PDE4D-007 59988441-60488065 retained_intron
  ENST00000512069 PDE4D-022 59558560-59988704 processed_transcript
  ENST00000514231 PDE4D-025 59215454-59988632 retained_intron
  ENST00000514552 PDE4D-021 59988536-60372714 protein_coding
  ENST00000515011 PDE4D-018 58974655-59039515 retained_intron
  ENST00000515324 PDE4D-024 59174350-59215935 processed_transcript
  ENST00000515835 PDE4D-010 59988602-60488063 protein_coding
  ENST00000546160 PDE4D-201 58969045-59217316 protein_coding
  ENST00000621323 PDE4D-026 59164947-59215968 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000502575ENST00000503258ENST00000505453ENST00000507116ENST00000546160
Transcript ID BECs HAoEC HUVEC
ENST00000502575 1.450±0.43 0.462±0.16 9.308±5.70
ENST00000503258 N/A N/A 4.233±2.94
ENST00000505453 N/A 0.235±0.00 N/A
ENST00000507116 N/A 0.226±0.00 N/A
ENST00000546160 N/A 0.106±0.00 2.504±0.55

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 ISS regulation of heart rate
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005794 IEA Golgi apparatus
GO:0005813 IEA centrosome
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0006939 IEA smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007568 IEA aging
GO:0007613 IEA memory
GO:0008144 IPI drug binding
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 ISS regulation of receptor activity
GO:0010738 IEA regulation of protein kinase A signaling
GO:0010880 ISS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0017124 IEA SH3 domain binding
GO:0019899 ISS enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0019933 NAS cAMP-mediated signaling
GO:0030016 IEA myofibril
GO:0030324 IEA lung development
GO:0030552 IDA cAMP binding
GO:0030593 IEA neutrophil chemotaxis
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031698 ISS beta-2 adrenergic receptor binding
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0032754 IMP positive regulation of interleukin-5 production
GO:0033137 ISS negative regulation of peptidyl-serine phosphorylation
GO:0034704 IDA calcium channel complex
GO:0035264 IEA multicellular organism growth
GO:0043623 IEA cellular protein complex assembly
GO:0044325 ISS ion channel binding
GO:0045822 ISS negative regulation of heart contraction
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IMP T cell receptor signaling pathway
GO:0050900 IEA leukocyte migration
GO:0051117 IPI ATPase binding
GO:0060314 ISS regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 ISS establishment of endothelial barrier
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071320 IDA cellular response to cAMP
GO:0071872 IDA cellular response to epinephrine stimulus
GO:0071875 ISS adrenergic receptor signaling pathway
GO:0086004 ISS regulation of cardiac muscle cell contraction
GO:0086024 IC adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:0097110 IPI scaffold protein binding
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 ISS negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032761 pde4d protein_coding Danio_rerio
ENSMUSG00000021699 Pde4d protein_coding Mus_musculus

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