ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: activin A receptor, type IIB
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114739 ACVR2B 9606 + 3:38453851-38493142 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000352511 ACVR2B-001 38453851-38493142 protein_coding
  ENST00000461232 ACVR2B-003 38473446-38483374 retained_intron
  ENST00000465020 ACVR2B-002 38454319-38483373 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000352511ENST00000461232ENST00000465020
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000352511 0.092±0.06 0.328±0.17 0.496±0.00 0.329±0.00 0.758±0.40
ENST00000461232 N/A N/A N/A 0.110±0.00 0.276±0.16
ENST00000465020 0.580±0.24 0.226±0.03 N/A 0.418±0.00 1.050±0.78

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008BE CIL_0008BE_0001 VISTA
CIL_0005W6 CIL_0005W6_0001 CGP
CIL_0005W0 CIL_0005W0_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IEA skeletal system development
GO:0001702 IEA gastrulation with mouth forming second
GO:0001822 IEA kidney development
GO:0001946 ISS lymphangiogenesis
GO:0001974 ISS blood vessel remodeling
GO:0004672 IEA protein kinase activity
GO:0004674 IMP protein serine/threonine kinase activity
GO:0004675 IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007178 TAS transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007368 IEA determination of left/right symmetry
GO:0007389 IEA pattern specification process
GO:0007498 IEA mesoderm development
GO:0007507 IEA heart development
GO:0009749 IEA response to glucose
GO:0009791 IEA post-embryonic development
GO:0009952 IMP anterior/posterior pattern specification
GO:0009966 IEA regulation of signal transduction
GO:0016020 IEA membrane
GO:0016362 TAS activin receptor activity, type II
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019838 IPI growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030073 IEA insulin secretion
GO:0030324 IEA lung development
GO:0030501 IMP positive regulation of bone mineralization
GO:0030509 IDA BMP signaling pathway
GO:0031016 IEA pancreas development
GO:0032147 IEA activation of protein kinase activity
GO:0032924 TAS activin receptor signaling pathway
GO:0032927 IDA positive regulation of activin receptor signaling pathway
GO:0034711 IEA inhibin binding
GO:0035265 IEA organ growth
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0043234 IPI protein complex
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0046872 IEA metal ion binding
GO:0048185 IEA activin binding
GO:0048617 IEA embryonic foregut morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0060021 IEA palate development
GO:0060836 ISS lymphatic endothelial cell differentiation
GO:0060840 ISS artery development
GO:0060841 ISS venous blood vessel development
GO:0061298 ISS retina vasculature development in camera-type eye

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044422 acvr2b protein_coding Danio_rerio
ENSMUSG00000061393 Acvr2b protein_coding Mus_musculus

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