ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: fibronectin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115414 FN1 9606 - 2:215360440-215436172 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000323926 FN1-002 215360454-215436068 protein_coding
  ENST00000336916 FN1-003 215360454-215436068 protein_coding
  ENST00000354785 FN1-001 215360454-215436172 protein_coding
  ENST00000356005 FN1-013 215360866-215436068 protein_coding
  ENST00000357867 FN1-004 215360454-215436068 protein_coding
  ENST00000359671 FN1-201 215360458-215436068 protein_coding
  ENST00000421182 FN1-005 215360440-215436067 protein_coding
  ENST00000426059 FN1-014 215414661-215436073 protein_coding
  ENST00000432072 FN1-012 215360865-215436067 protein_coding
  ENST00000438981 FN1-026 215371909-215375689 protein_coding
  ENST00000443816 FN1-009 215360862-215436073 protein_coding
  ENST00000446046 FN1-008 215360862-215436068 protein_coding
  ENST00000456923 FN1-011 215361147-215393147 protein_coding
  ENST00000460217 FN1-025 215371864-215375725 retained_intron
  ENST00000461974 FN1-022 215370343-215372482 retained_intron
  ENST00000469569 FN1-018 215364370-215365517 retained_intron
  ENST00000471193 FN1-031 215408319-215409950 retained_intron
  ENST00000473614 FN1-019 215364667-215365753 retained_intron
  ENST00000474036 FN1-027 215375633-215381329 retained_intron
  ENST00000480024 FN1-021 215367679-215370520 retained_intron
  ENST00000480737 FN1-024 215382159-215384080 retained_intron
  ENST00000485567 FN1-023 215370380-215372439 retained_intron
  ENST00000490833 FN1-028 215379205-215383483 processed_transcript
  ENST00000492816 FN1-007 215360862-215393721 retained_intron
  ENST00000494446 FN1-017 215361341-215365676 retained_intron
  ENST00000496542 FN1-032 215419289-215421270 retained_intron
  ENST00000498719 FN1-010 215360866-215363640 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000323926ENST00000336916ENST00000356005ENST00000357867ENST00000359671ENST00000426059ENST00000432072ENST00000443816ENST00000446046ENST00000456923ENST00000474036ENST00000480024ENST00000492816ENST00000498719
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000323926 N/A N/A N/A N/A 47.195±0.00
ENST00000336916 N/A N/A N/A N/A 87.329±40.06
ENST00000356005 N/A 39.347±12.32 N/A N/A 223.186±157.38
ENST00000357867 N/A N/A N/A N/A 26.105±2.51
ENST00000359671 N/A N/A N/A N/A 39.496±4.44
ENST00000426059 N/A 169.374±0.00 N/A N/A 381.265±278.65
ENST00000432072 N/A N/A N/A N/A 0.002±0.00
ENST00000443816 N/A 509.217±150.27 N/A 555.109±0.00 265.864±146.81
ENST00000446046 N/A 547.563±233.24 3.394±0.00 717.565±0.00 324.512±223.94
ENST00000456923 108.948±0.00 N/A 3.683±0.00 N/A 285.088±141.68
ENST00000474036 N/A N/A N/A N/A 0.009±0.00
ENST00000480024 N/A N/A N/A N/A 0.031±0.00
ENST00000492816 N/A N/A N/A N/A 15.349±15.35
ENST00000498719 N/A N/A N/A N/A 0.006±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005MI CIL_0005MI_0001 CGP
CIL_0005MJ CIL_0005MJ_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0002020 IPI protease binding
GO:0002576 TAS platelet degranulation
GO:0005178 IDA integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005518 NAS collagen binding
GO:0005576 NAS:IEA extracellular region
GO:0005577 IDA fibrinogen complex
GO:0005604 IEA basement membrane
GO:0005605 IEA basal lamina
GO:0005615 IDA extracellular space
GO:0005793 IDA endoplasmic reticulum-Golgi intermediate compartment
GO:0006953 IEA acute-phase response
GO:0007044 IEA cell-substrate junction assembly
GO:0007155 NAS cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007161 IEA calcium-independent cell-matrix adhesion
GO:0007596 TAS blood coagulation
GO:0008201 NAS heparin binding
GO:0008360 IEA regulation of cell shape
GO:0009611 NAS response to wounding
GO:0010952 IEA positive regulation of peptidase activity
GO:0016324 IEA apical plasma membrane
GO:0016504 IEA peptidase activator activity
GO:0018149 IDA peptide cross-linking
GO:0022617 TAS extracellular matrix disassembly
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0031012 IDA extracellular matrix
GO:0031093 TAS platelet alpha granule lumen
GO:0033622 IMP integrin activation
GO:0034446 IDA substrate adhesion-dependent cell spreading
GO:0035987 IDA endodermal cell differentiation
GO:0042060 IEA wound healing
GO:0045773 IEA positive regulation of axon extension
GO:0050900 TAS leukocyte migration
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006526 fn1b protein_coding Danio_rerio
ENSDARG00000019815 fn1a protein_coding Danio_rerio
ENSMUSG00000026193 Fn1 protein_coding Mus_musculus

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