ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: AP2 associated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115977 AAK1 9606 - 2:69457995-69674349 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339092 AAK1-201 69457995-69643845 protein_coding
  ENST00000406297 AAK1-002 69481056-69643717 protein_coding
  ENST00000409068 AAK1-011 69461400-69643654 protein_coding
  ENST00000409085 AAK1-001 69467787-69643717 protein_coding
  ENST00000461002 AAK1-007 69643085-69674349 processed_transcript
  ENST00000470281 AAK1-006 69531717-69544509 processed_transcript
  ENST00000471775 AAK1-010 69642906-69643950 processed_transcript
  ENST00000489327 AAK1-005 69478456-69509493 retained_intron
  ENST00000492192 AAK1-009 69643093-69643845 processed_transcript
  ENST00000495239 AAK1-008 69642877-69643960 processed_transcript
  ENST00000495836 AAK1-003 69544239-69643717 retained_intron
  ENST00000606389 AAK1-012 69457997-69509280 protein_coding
  ENST00000623317 AAK1-013 69465846-69509280 protein_coding
  ENST00000624900 AAK1-014 69499869-69509262 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000339092ENST00000406297ENST00000409068ENST00000409085ENST00000495836ENST00000606389
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000339092 N/A 2.002±0.00 N/A N/A 1.537±0.57
ENST00000406297 N/A N/A N/A N/A 3.010±0.39
ENST00000409068 N/A 6.837±2.02 N/A N/A 6.942±3.36
ENST00000409085 N/A N/A N/A N/A 1.378±0.00
ENST00000495836 N/A N/A N/A N/A 10.880±2.06
ENST00000606389 0.613±0.09 3.661±1.66 0.543±0.00 0.819±0.00 4.062±2.31

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0000YR CIL_0000YR_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005112 IDA Notch binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005905 IEA coated pit
GO:0006468 IEA protein phosphorylation
GO:0006897 IEA endocytosis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019897 ISS extrinsic component of plasma membrane
GO:0030136 ISS clathrin-coated vesicle
GO:0031252 ISS cell leading edge
GO:0032880 IDA regulation of protein localization
GO:0035612 IDA AP-2 adaptor complex binding
GO:0043195 ISS terminal bouton
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0046777 ISS protein autophosphorylation
GO:0050821 IDA protein stabilization
GO:2000369 IMP regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011855 aak1a protein_coding Danio_rerio
ENSDARG00000077686 aak1b protein_coding Danio_rerio
ENSMUSG00000057230 Aak1 protein_coding Mus_musculus

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