ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: isoprenylcysteine carboxyl methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116237 ICMT 9606 - 1:6221193-6235972 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343813 ICMT-001 6221193-6235940 protein_coding
  ENST00000474756 ICMT-006 6224599-6235972 nonsense_mediated_decay
  ENST00000489498 ICMT-002 6223491-6235972 nonsense_mediated_decay
  ENST00000495791 ICMT-005 6221898-6223502 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000343813ENST00000474756ENST00000489498
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000343813 22.172±6.80 27.934±0.00 15.598±9.36
ENST00000474756 N/A N/A 1.574±0.00
ENST00000489498 24.112±6.21 N/A 8.225±5.57

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00019L CIL_00019L_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0003880 TAS protein C-terminal carboxyl O-methyltransferase activity
GO:0004671 IEA protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0005783 IDA endoplasmic reticulum
GO:0006464 TAS cellular protein modification process
GO:0006479 IEA protein methylation
GO:0006481 IEA C-terminal protein methylation
GO:0006612 TAS protein targeting to membrane
GO:0008104 IEA protein localization
GO:0008140 IEA cAMP response element binding protein binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0016020 TAS membrane
GO:0016021 IEA integral component of membrane
GO:0035264 IEA multicellular organism growth
GO:0046578 IEA regulation of Ras protein signal transduction
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020241 icmt protein_coding Danio_rerio
ENSMUSG00000039662 Icmt protein_coding Mus_musculus

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