ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: leucine proline-enriched proteoglycan (leprecan) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117385 LEPRE1 9606 - 1:42746335-42767084 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000236040 LEPRE1-002 42746375-42767012 protein_coding
  ENST00000296388 LEPRE1-001 42746375-42767023 protein_coding
  ENST00000372526 LEPRE1-012 42759257-42767002 protein_coding
  ENST00000397054 LEPRE1-201 42746335-42767084 protein_coding
  ENST00000431412 LEPRE1-008 42747723-42755209 nonsense_mediated_decay
  ENST00000447502 LEPRE1-011 42751725-42754987 protein_coding
  ENST00000460031 LEPRE1-009 42746374-42766989 retained_intron
  ENST00000460831 LEPRE1-005 42747758-42748743 retained_intron
  ENST00000462474 LEPRE1-007 42746508-42747798 processed_transcript
  ENST00000463465 LEPRE1-010 42754980-42762403 retained_intron
  ENST00000472802 LEPRE1-006 42746531-42747576 retained_intron
  ENST00000481465 LEPRE1-013 42749901-42754936 retained_intron
  ENST00000492956 LEPRE1-003 42759986-42767017 retained_intron
  ENST00000495874 LEPRE1-004 42746375-42767022 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000236040ENST00000296388ENST00000372526ENST00000397054ENST00000431412ENST00000460031ENST00000462474ENST00000495874
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000236040 7.304±0.00 N/A 9.091±0.00 N/A 10.914±2.59
ENST00000296388 25.727±8.58 41.516±14.11 N/A 32.078±0.00 40.458±24.92
ENST00000372526 N/A N/A N/A N/A 0.595±0.00
ENST00000397054 N/A 7.254±3.53 N/A 8.731±0.00 12.490±7.35
ENST00000431412 46.461±0.00 N/A N/A N/A N/A
ENST00000460031 N/A N/A 7.425±0.00 N/A 19.405±0.51
ENST00000462474 206.491±25.20 N/A 42.678±0.00 N/A N/A
ENST00000495874 N/A N/A N/A N/A 7.641±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008PM CIL_0008PM_0001 VISTA
CIL_0005B1 CIL_0005B1_0002 CGP
CIL_0005B2 CIL_0005B2_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003674 ND molecular_function
GO:0005506 IEA iron ion binding
GO:0005518 ISS collagen binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006457 IMP protein folding
GO:0008285 NAS negative regulation of cell proliferation
GO:0016020 IDA membrane
GO:0016049 IEA cell growth
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018126 IMP protein hydroxylation
GO:0019511 IEA peptidyl-proline hydroxylation
GO:0019797 ISS procollagen-proline 3-dioxygenase activity
GO:0030198 TAS extracellular matrix organization
GO:0030199 IEA collagen fibril organization
GO:0030278 IEA regulation of ossification
GO:0031418 IEA L-ascorbic acid binding
GO:0032403 ISS protein complex binding
GO:0032963 ISS collagen metabolic process
GO:0032991 ISS macromolecular complex
GO:0050708 IMP regulation of protein secretion
GO:0050821 IMP protein stabilization
GO:0055114 IEA oxidation-reduction process
GO:0060348 IMP bone development
GO:0061077 ISS chaperone-mediated protein folding
GO:0070062 IDA extracellular vesicular exosome
GO:1901874 IMP negative regulation of post-translational protein modification

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071212 p3h1 protein_coding Danio_rerio
ENSMUSG00000028641 P3h1 protein_coding Mus_musculus

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