ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: integrin beta 1 binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119185 ITGB1BP1 9606 - 2:9403475-9423547 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000238091 ITGB1BP1-002 9405684-9423506 protein_coding
  ENST00000355346 ITGB1BP1-001 9405684-9423547 protein_coding
  ENST00000359712 ITGB1BP1-004 9406661-9423250 protein_coding
  ENST00000360635 ITGB1BP1-005 9403475-9423229 protein_coding
  ENST00000456913 ITGB1BP1-011 9407030-9423430 protein_coding
  ENST00000460001 ITGB1BP1-016 9412304-9423176 protein_coding
  ENST00000460720 ITGB1BP1-021 9406661-9408299 retained_intron
  ENST00000463190 ITGB1BP1-008 9408002-9423522 retained_intron
  ENST00000464228 ITGB1BP1-006 9406660-9423500 nonsense_mediated_decay
  ENST00000465527 ITGB1BP1-019 9406661-9412717 retained_intron
  ENST00000467606 ITGB1BP1-014 9412269-9423087 protein_coding
  ENST00000470507 ITGB1BP1-020 9406814-9408404 retained_intron
  ENST00000482798 ITGB1BP1-017 9407543-9422566 processed_transcript
  ENST00000483795 ITGB1BP1-003 9405694-9423456 nonsense_mediated_decay
  ENST00000484735 ITGB1BP1-012 9412297-9423340 protein_coding
  ENST00000488451 ITGB1BP1-009 9406667-9423480 protein_coding
  ENST00000490426 ITGB1BP1-007 9406349-9423462 processed_transcript
  ENST00000492079 ITGB1BP1-018 9407572-9420294 protein_coding
  ENST00000494563 ITGB1BP1-013 9408152-9423176 protein_coding
  ENST00000497031 ITGB1BP1-010 9406648-9423444 processed_transcript
  ENST00000497105 ITGB1BP1-015 9412360-9423228 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000355346ENST00000359712ENST00000360635ENST00000460720ENST00000464228
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000355346 N/A N/A N/A N/A 13.403±2.44
ENST00000359712 7.462±0.00 N/A N/A N/A N/A
ENST00000360635 6.600±0.36 8.646±2.79 N/A N/A 5.762±1.13
ENST00000460720 132.226±33.84 76.483±13.31 46.728±0.00 N/A N/A
ENST00000464228 33.641±0.00 28.337±0.00 N/A 31.657±0.00 36.367±16.59

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007AP CIL_0007AP_0002 CGP
CIL_0007AV CIL_0007AV_0002 CGP
CIL_00057K CIL_00057K_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IDA ruffle
GO:0002043 IDA blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0005092 IDA GDP-dissociation inhibitor activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005856 ISS cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006469 IDA negative regulation of protein kinase activity
GO:0006933 ISS negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007160 IDA cell-matrix adhesion
GO:0007219 IEA Notch signaling pathway
GO:0007229 IDA integrin-mediated signaling pathway
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008565 IDA protein transporter activity
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010764 ISS negative regulation of fibroblast migration
GO:0015031 IDA protein transport
GO:0016020 NAS membrane
GO:0016477 TAS cell migration
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030154 IEA cell differentiation
GO:0031214 IEA biomineral tissue development
GO:0032091 IDA negative regulation of protein binding
GO:0032148 IDA activation of protein kinase B activity
GO:0032403 IDA protein complex binding
GO:0033622 ISS integrin activation
GO:0033628 ISS regulation of cell adhesion mediated by integrin
GO:0035148 IDA tube formation
GO:0035556 TAS intracellular signal transduction
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0043088 IDA regulation of Cdc42 GTPase activity
GO:0043113 ISS receptor clustering
GO:0044344 IDA cellular response to fibroblast growth factor stimulus
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050880 IDA regulation of blood vessel size
GO:0051451 ISS myoblast migration
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0051781 IEA positive regulation of cell division
GO:0051894 IEA positive regulation of focal adhesion assembly
GO:0051895 IDA negative regulation of focal adhesion assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0070062 IDA extracellular vesicular exosome
GO:0070373 IDA negative regulation of ERK1 and ERK2 cascade
GO:0071944 IDA cell periphery
GO:0090051 IDA negative regulation of cell migration involved in sprouting angiogenesis
GO:0090314 ISS positive regulation of protein targeting to membrane
GO:0090315 IDA negative regulation of protein targeting to membrane
GO:1900025 IDA negative regulation of substrate adhesion-dependent cell spreading
GO:2001044 ISS regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007169 itgb1bp1 protein_coding Danio_rerio
ENSMUSG00000062352 Itgb1bp1 protein_coding Mus_musculus

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