ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062352 Itgb1bp1 10090 - 12:21269806-21286237 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000076260 Itgb1bp1-001 21269806-21286237 protein_coding
  ENSMUST00000172834 Itgb1bp1-006 21271288-21286185 protein_coding
  ENSMUST00000173614 Itgb1bp1-007 21271426-21272770 retained_intron
  ENSMUST00000173688 Itgb1bp1-005 21270704-21272123 protein_coding
  ENSMUST00000173729 Itgb1bp1-004 21270093-21286097 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; Tie2+ ECmESENSMUST00000076260ENSMUST00000172834ENSMUST00000173729
Transcript ID Tie2+ EC mES
ENSMUST00000076260 6.492±0.83 11.364±2.38
ENSMUST00000172834 15.918±2.72 N/A
ENSMUST00000173729 5.644±0.36 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007AV CIL_0007AV_0003 CGP
CIL_00057K CIL_00057K_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0002043 ISS blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0005092 ISS GDP-dissociation inhibitor activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006933 IDA negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007160 ISS cell-matrix adhesion
GO:0007219 IEA Notch signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008565 ISS protein transporter activity
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0010764 IDA negative regulation of fibroblast migration
GO:0015031 ISS protein transport
GO:0019900 IPI kinase binding
GO:0019901 IDA protein kinase binding
GO:0030027 ISS lamellipodium
GO:0030154 IEA cell differentiation
GO:0031214 IEA biomineral tissue development
GO:0032091 ISS negative regulation of protein binding
GO:0032148 ISS activation of protein kinase B activity
GO:0032403 ISS protein complex binding
GO:0033622 IDA integrin activation
GO:0033628 IMP regulation of cell adhesion mediated by integrin
GO:0035148 ISS tube formation
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043113 IDA receptor clustering
GO:0044344 ISS cellular response to fibroblast growth factor stimulus
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050880 ISS regulation of blood vessel size
GO:0051451 IMP myoblast migration
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051781 IEA positive regulation of cell division
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0051895 IMP negative regulation of focal adhesion assembly
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0070062 IEA extracellular vesicular exosome
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0071944 ISS cell periphery
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:0090314 IDA positive regulation of protein targeting to membrane
GO:0090315 ISS negative regulation of protein targeting to membrane
GO:1900025 ISS negative regulation of substrate adhesion-dependent cell spreading
GO:2001044 IDA regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007169 itgb1bp1 protein_coding Danio_rerio
ENSG00000119185 ITGB1BP1 integrin beta 1 binding protein 1 protein_coding Homo_sapiens

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