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                ),
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$value = array(
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)
$config = '_cake_core_'
$settings = array(
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	'path' => '/var/www/angiogenes/app/tmp/cache/persistent/',
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	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
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$value = null
$config = '_cake_model_'
$settings = array(
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	'path' => '/var/www/angiogenes/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
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$key = 'default_angiogenes_list'
$value = array(
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	(int) 4 => 'go_annotations',
	(int) 5 => 'homologues',
	(int) 6 => 'repeats',
	(int) 7 => 'study',
	(int) 8 => 'synonyms',
	(int) 9 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
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	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
            );
$key = 'default_angiogenes_genes'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/angiogenes/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

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                ),
                E_USER_WARNING
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$config = '_cake_model_'
$settings = array(
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	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

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Gene Info
Description:	DNA (cytosine-5-)-methyltransferase 3 alpha
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000119772	DNMT3A	9606	-	2:25227855-25342590	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000264709		DNMT3A-001	25227855-25342590	protein_coding
	ENST00000321117		DNMT3A-011	25232976-25341885	protein_coding
	ENST00000380746		DNMT3A-002	25232976-25252311	protein_coding
	ENST00000380756		DNMT3A-010	25232977-25342489	nonsense_mediated_decay
	ENST00000402667		DNMT3A-013	25234197-25252311	protein_coding
	ENST00000406659		DNMT3A-012	25281452-25342590	protein_coding
	ENST00000461228		DNMT3A-006	25239176-25243982	processed_transcript
	ENST00000466601		DNMT3A-007	25236974-25242015	retained_intron
	ENST00000470983		DNMT3A-003	25246757-25249703	processed_transcript
	ENST00000474807		DNMT3A-004	25245262-25247899	retained_intron
	ENST00000474887		DNMT3A-008	25235706-25244324	processed_transcript
	ENST00000482935		DNMT3A-015	25235785-25243979	processed_transcript
	ENST00000484184		DNMT3A-005	25246674-25247566	retained_intron
	ENST00000491288		DNMT3A-009	25236930-25243970	processed_transcript
	ENST00000496570		DNMT3A-017	25247050-25252083	processed_transcript

Expression Patterns Split around values. Cell Line Name Tissue Condition Heat Map Numeric Values Transcript ID BECs CECs HAoEC HHSEC HMVEC-D HUVEC ENST00000264709 N/A 296.641±180.09 0.494±0.22 N/A N/A 1.443±0.29 ENST00000321117 1.132±0.00 N/A 1.259±0.59 N/A 3.608±0.00 2.819±0.84 ENST00000380746 2.390±0.26 N/A 2.398±1.43 4.160±0.00 N/A 3.201±1.93 ENST00000402667 N/A N/A 0.818±0.00 N/A N/A 4.086±1.50

Conserved Regions
Region ID	Sub-Region	Region Type
CIL_0003JL	CIL_0003JL_0002	CGP

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0000122	IEA	negative regulation of transcription from RNA polymerase II promoter
GO:0000775	IEA	chromosome, centromeric region
GO:0000791	IDA	euchromatin
GO:0000792	IEA	heterochromatin
GO:0001741	IEA	XY body
GO:0003677	IDA	DNA binding
GO:0003682	IEA	chromatin binding
GO:0003886	IDA	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	IPI	protein binding
GO:0005634	IDA	nucleus
GO:0005720	IEA	nuclear heterochromatin
GO:0005737	IDA	cytoplasm
GO:0006306	IDA	DNA methylation
GO:0006346	IEA	methylation-dependent chromatin silencing
GO:0006349	TAS	regulation of gene expression by genetic imprinting
GO:0007283	IEA	spermatogenesis
GO:0008168	IEA	methyltransferase activity
GO:0010424	IEA	DNA methylation on cytosine within a CG sequence
GO:0016363	IDA	nuclear matrix
GO:0042802	IPI	identical protein binding
GO:0043045	IEA	DNA methylation involved in embryo development
GO:0043046	IEA	DNA methylation involved in gamete generation
GO:0044027	IEA	hypermethylation of CpG island
GO:0045322	IEA	unmethylated CpG binding
GO:0046498	IEA	S-adenosylhomocysteine metabolic process
GO:0046499	IEA	S-adenosylmethioninamine metabolic process
GO:0046872	IEA	metal ion binding
GO:0051718	IEA	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0071230	IEA	cellular response to amino acid stimulus
GO:0090116	IEA	C-5 methylation of cytosine

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000005394	dnmt3aa		protein_coding	Danio_rerio
ENSDARG00000015566	dnmt3ab		protein_coding	Danio_rerio
ENSMUSG00000020661	Dnmt3a		protein_coding	Mus_musculus

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

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                ),
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		'b93574bf8a03f2d6f6486e920115e0d1' => '`Gene`.`annotation_version`',
		'1c4a3f5d90070e8ea1c62ca077df603e' => '`Gene`.`gene_description`',
		'8ca7a0c53312b8ae3cfa40a9d814adac' => '`Gene`'
	),
	'fields' => array(
		'47cba37bb7792f95f7499f6996d48351' => array(
			(int) 0 => '`Gene`.`id`',
			(int) 1 => '`Gene`.`gene_version`',
			(int) 2 => '`Gene`.`tax_id`',
			(int) 3 => '`Gene`.`assembly`',
			(int) 4 => '`Gene`.`chromosome`',
			(int) 5 => '`Gene`.`strand`',
			(int) 6 => '`Gene`.`start`',
			(int) 7 => '`Gene`.`end`',
			(int) 8 => '`Gene`.`gene_name`',
			(int) 9 => '`Gene`.`gene_source`',
			(int) 10 => '`Gene`.`gene_biotype`',
			(int) 11 => '`Gene`.`annotation_version`',
			(int) 12 => '`Gene`.`gene_description`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/angiogenes/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??