ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: nuclear receptor subfamily 4, group A, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000123358 NR4A1 9606 + 12:52022832-52059507 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000243050 NR4A1-201 52051402-52059506 protein_coding
  ENST00000360284 NR4A1-202 52022832-52059506 protein_coding
  ENST00000394824 NR4A1-002 52051442-52059507 protein_coding
  ENST00000394825 NR4A1-203 52051402-52059506 protein_coding
  ENST00000478250 NR4A1-001 52043727-52055961 retained_intron
  ENST00000545748 NR4A1-003 52037715-52059501 protein_coding
  ENST00000546842 NR4A1-012 52037177-52055197 protein_coding
  ENST00000547206 NR4A1-009 52043839-52054673 processed_transcript
  ENST00000548232 NR4A1-006 52051448-52055306 protein_coding
  ENST00000548733 NR4A1-014 52051463-52057425 processed_transcript
  ENST00000548977 NR4A1-011 52022832-52054646 protein_coding
  ENST00000549102 NR4A1-008 52043425-52054439 retained_intron
  ENST00000550082 NR4A1-004 52041805-52059049 protein_coding
  ENST00000550339 NR4A1-017 52056022-52056855 retained_intron
  ENST00000550557 NR4A1-005 52053418-52059503 retained_intron
  ENST00000550582 NR4A1-016 52056604-52058703 protein_coding
  ENST00000550763 NR4A1-013 52051442-52056151 protein_coding
  ENST00000553200 NR4A1-010 52037242-52045568 protein_coding
  ENST00000562373 NR4A1-021 52051459-52054882 protein_coding
  ENST00000564201 NR4A1-019 52055721-52056804 retained_intron
  ENST00000565848 NR4A1-018 52056689-52057471 retained_intron
  ENST00000567890 NR4A1-020 52056145-52057139 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000243050ENST00000478250ENST00000545748ENST00000546842ENST00000547206ENST00000548232ENST00000548977ENST00000550082ENST00000550557ENST00000550582ENST00000550763
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000243050 N/A 0.150±0.02 N/A N/A N/A
ENST00000478250 N/A N/A N/A N/A 0.549±0.00
ENST00000545748 0.081±0.00 0.055±0.02 N/A N/A 0.366±0.22
ENST00000546842 N/A 0.127±0.11 N/A N/A 1.113±0.52
ENST00000547206 N/A 0.303±0.00 N/A N/A N/A
ENST00000548232 N/A 4.412±5.93 N/A N/A 4.316±3.30
ENST00000548977 1.195±0.00 N/A N/A N/A N/A
ENST00000550082 N/A 6.570±5.86 276.289±0.00 0.485±0.00 2.377±1.52
ENST00000550557 N/A 0.034±0.00 N/A 0.165±0.00 1.573±1.27
ENST00000550582 1.545±0.31 0.425±0.05 N/A N/A 0.660±0.00
ENST00000550763 N/A 21.540±2.30 N/A N/A 227.116±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006K0 CIL_0006K0_0001 CGP
CIL_0006JQ CIL_0006JQ_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0002042 IDA cell migration involved in sprouting angiogenesis
GO:0003677 ISS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008270 IEA zinc ion binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010467 TAS gene expression
GO:0030522 IEA intracellular receptor signaling pathway
GO:0035767 IMP endothelial cell chemotaxis
GO:0035914 IEA skeletal muscle cell differentiation
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042803 IEA protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044344 IMP cellular response to fibroblast growth factor stimulus
GO:0045087 TAS innate immune response
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0071310 IEA cellular response to organic substance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000796 nr4a1 protein_coding Danio_rerio
ENSMUSG00000023034 Nr4a1 protein_coding Mus_musculus

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