ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: phospholipase C, gamma 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124181 PLCG1 9606 + 20:41136960-41196787 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000244007 PLCG1-013 41136960-41175721 protein_coding
  ENST00000373271 PLCG1-005 41137237-41175721 protein_coding
  ENST00000423733 PLCG1-020 41180456-41196787 processed_transcript
  ENST00000461641 PLCG1-012 41172411-41174312 retained_intron
  ENST00000465571 PLCG1-003 41165807-41166880 retained_intron
  ENST00000470528 PLCG1-008 41163174-41164005 retained_intron
  ENST00000473632 PLCG1-002 41165280-41165860 retained_intron
  ENST00000477870 PLCG1-004 41167657-41170618 retained_intron
  ENST00000483175 PLCG1-011 41167916-41170910 retained_intron
  ENST00000483646 PLCG1-007 41137732-41162647 processed_transcript
  ENST00000490253 PLCG1-006 41137550-41159823 retained_intron
  ENST00000492148 PLCG1-001 41162962-41163982 retained_intron
  ENST00000599785 PLCG1-014 41170189-41182989 nonsense_mediated_decay
  ENST00000607954 PLCG1-016 41173804-41182989 nonsense_mediated_decay
  ENST00000608689 PLCG1-015 41172439-41182989 processed_transcript
  ENST00000608885 PLCG1-019 41172516-41182989 nonsense_mediated_decay
  ENST00000609257 PLCG1-018 41173731-41182960 nonsense_mediated_decay
  ENST00000609821 PLCG1-017 41173507-41182960 processed_transcript
  ENST00000612731 PLCG1-021 41168841-41176281 processed_transcript
  ENST00000617873 PLCG1-022 41166728-41169628 processed_transcript
  ENST00000619272 PLCG1-023 41168799-41170251 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000244007ENST00000609257
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000244007 14.850±2.66 28.974±8.33 40.223±0.00 13.852±0.00 31.426±17.56
ENST00000609257 33.556±0.00 N/A 83.007±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007XA CIL_0007XA_0001 VISTA
CIL_0008MI CIL_0008MI_0001 VISTA
CIL_0008QO CIL_0008QO_0001 VISTA
CIL_0009AV CIL_0009AV_0001 VISTA
CIL_0004EC CIL_0004EC_0001 CGP
CIL_0002I4 CIL_0002I4_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 TAS activation of MAPKK activity
GO:0001701 IEA in utero embryonic development
GO:0001726 IDA ruffle
GO:0004435 IDA:IEA phosphatidylinositol phospholipase C activity
GO:0004629 TAS phospholipase C activity
GO:0004871 IEA signal transducer activity
GO:0005057 NAS receptor signaling protein activity
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006629 IEA lipid metabolic process
GO:0007165 NAS:IEA signal transduction
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008152 IEA metabolic process
GO:0008180 IDA COP9 signalosome
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009395 IEA phospholipid catabolic process
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0016032 IEA viral process
GO:0016042 IEA lipid catabolic process
GO:0016477 IMP cell migration
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019722 IMP calcium-mediated signaling
GO:0019901 IPI protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030971 IEA receptor tyrosine kinase binding
GO:0035254 IEA glutamate receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 IDA cell projection
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045766 IDA positive regulation of angiogenesis
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050852 TAS T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0051281 IMP positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 IDA cellular response to epidermal growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000016933 Plcg1 protein_coding Mus_musculus

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