ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: activating transcription factor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128272 ATF4 9606 + 22:39519695-39522685 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337304 ATF4-002 39520564-39522683 protein_coding
  ENST00000396680 ATF4-201 39520564-39522685 protein_coding
  ENST00000404241 ATF4-001 39519695-39522683 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000337304ENST00000396680
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000337304 N/A 3.716±0.22 25.591±0.00 17.044±0.00 25.733±32.34
ENST00000396680 174.947±33.72 80.779±30.26 201.718±0.00 90.048±0.00 179.433±127.68

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003MS CIL_0003MS_0001 CGP
CIL_0005W7 CIL_0005W7_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IC sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 ISS core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 ISS DNA binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 ISS cytoplasm
GO:0005856 IEA cytoskeleton
GO:0006094 ISS gluconeogenesis
GO:0006355 ISS:IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 ISS transcription from RNA polymerase II promoter
GO:0006520 TAS cellular amino acid metabolic process
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0007623 IEA circadian rhythm
GO:0008022 IEA protein C-terminus binding
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0032590 IEA dendrite membrane
GO:0032922 ISS circadian regulation of gene expression
GO:0034399 IDA nuclear periphery
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0036091 IMP positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043005 IDA neuron projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044267 TAS cellular protein metabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0070059 ISS intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1903204 IGI negative regulation of oxidative stress-induced neuron death
GO:1990037 IDA Lewy body core
GO:1990440 IMP positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038141 atf4b protein_coding Danio_rerio
ENSDARG00000039515 atf4a protein_coding Danio_rerio
ENSMUSG00000042406 Atf4 protein_coding Mus_musculus

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