ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128731 HERC2 9606 - 15:28111040-28322152 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261609 HERC2-001 28111040-28322152 protein_coding
  ENST00000562136 HERC2-008 28111762-28113717 retained_intron
  ENST00000563670 HERC2-007 28272044-28273168 retained_intron
  ENST00000563945 HERC2-002 28320122-28322119 processed_transcript
  ENST00000564383 HERC2-009 28280034-28299483 retained_intron
  ENST00000564519 HERC2-012 28141739-28142452 retained_intron
  ENST00000564734 HERC2-003 28254488-28322149 nonsense_mediated_decay
  ENST00000566635 HERC2-006 28111279-28117551 retained_intron
  ENST00000567869 HERC2-004 28190201-28203936 retained_intron
  ENST00000568206 HERC2-005 28115281-28118421 retained_intron
  ENST00000569335 HERC2-010 28222148-28229516 retained_intron
  ENST00000569772 HERC2-011 28152759-28174423 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000261609ENST00000566635ENST00000567869
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000261609 0.791±0.19 3.990±1.30 N/A 4.986±0.00 4.005±1.85
ENST00000566635 3.819±1.93 N/A 13.593±0.00 N/A 10.721±2.96
ENST00000567869 N/A N/A N/A N/A 5.357±2.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005085 NAS guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005856 IEA cytoskeleton
GO:0006281 IDA DNA repair
GO:0006886 NAS intracellular protein transport
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007283 IEA spermatogenesis
GO:0008270 IEA zinc ion binding
GO:0016020 IDA membrane
GO:0016567 IDA:IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0020037 IEA heme binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032183 IDA SUMO binding
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073841 herc2 protein_coding Danio_rerio
ENSMUSG00000030451 Herc2 protein_coding Mus_musculus

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