ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Raf-1 proto-oncogene, serine/threonine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132155 RAF1 9606 - 3:12583601-12664226 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251849 RAF1-001 12583601-12664226 protein_coding
  ENST00000416093 RAF1-010 12604135-12664125 nonsense_mediated_decay
  ENST00000423275 RAF1-006 12584333-12664125 nonsense_mediated_decay
  ENST00000432427 RAF1-008 12584267-12612005 protein_coding
  ENST00000442415 RAF1-007 12583798-12664148 protein_coding
  ENST00000460610 RAF1-005 12590641-12599755 retained_intron
  ENST00000465826 RAF1-004 12586847-12604213 retained_intron
  ENST00000471449 RAF1-009 12584346-12585905 retained_intron
  ENST00000475353 RAF1-012 12587577-12592068 retained_intron
  ENST00000491290 RAF1-011 12600199-12608867 retained_intron
  ENST00000492690 RAF1-003 12608446-12612001 retained_intron
  ENST00000494557 RAF1-002 12587979-12591916 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000251849ENST00000471449
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000251849 3.012±0.00 18.022±9.14 N/A 21.561±0.00 21.478±9.14
ENST00000471449 N/A N/A 33.370±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0004KF CIL_0004KF_0001 CGP
CIL_0005SJ CIL_0005SJ_0001 CGP
CIL_0005SC CIL_0005SC_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0001666 IEA response to hypoxia
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005057 IEA receptor signaling protein activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005741 TAS mitochondrial outer membrane
GO:0005794 IPI Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0007165 TAS:IEA signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007190 NAS activation of adenylate cyclase activity
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017016 IEA Ras GTPase binding
GO:0030154 IEA cell differentiation
GO:0030168 TAS platelet activation
GO:0031143 IEA pseudopodium
GO:0031333 IDA negative regulation of protein complex assembly
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034220 TAS ion transmembrane transport
GO:0035019 IEA somatic stem cell maintenance
GO:0035023 TAS regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 TAS wound healing
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043154 TAS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0045104 IEA intermediate filament cytoskeleton organization
GO:0045595 TAS regulation of cell differentiation
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0055085 TAS transmembrane transport
GO:0071550 IEA death-inducing signaling complex assembly
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000145 TAS regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059406 raf1b protein_coding Danio_rerio
ENSDARG00000096415 raf1a protein_coding Danio_rerio
ENSMUSG00000000441 Raf1 protein_coding Mus_musculus

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