ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132386 SERPINF1 9606 + 17:1761959-1777574 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000254722 SERPINF1-001 1761959-1777574 protein_coding
  ENST00000570731 SERPINF1-003 1762829-1771141 protein_coding
  ENST00000570820 SERPINF1-008 1770526-1772032 retained_intron
  ENST00000571149 SERPINF1-011 1762112-1770028 protein_coding
  ENST00000571360 SERPINF1-010 1762029-1771169 protein_coding
  ENST00000571870 SERPINF1-005 1762061-1771930 processed_transcript
  ENST00000572048 SERPINF1-013 1771719-1776604 protein_coding
  ENST00000572517 SERPINF1-007 1776450-1777565 retained_intron
  ENST00000573763 SERPINF1-012 1771719-1777209 protein_coding
  ENST00000573770 SERPINF1-006 1762068-1771972 nonsense_mediated_decay
  ENST00000576406 SERPINF1-009 1762068-1776578 protein_coding
  ENST00000577053 SERPINF1-004 1766274-1771080 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000254722ENST00000570820ENST00000572048ENST00000572517ENST00000573763ENST00000573770ENST00000577053
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000254722 0.256±0.00 0.059±0.05 N/A N/A 0.060±0.01
ENST00000570820 N/A N/A N/A 0.445±0.00 0.139±0.09
ENST00000572048 0.615±0.38 0.163±0.00 N/A N/A 0.145±0.10
ENST00000572517 1.452±1.28 0.553±0.34 11.128±0.00 0.732±0.00 0.414±0.33
ENST00000573763 N/A 0.767±0.00 N/A N/A 0.029±0.00
ENST00000573770 N/A N/A N/A N/A 0.028±0.00
ENST00000577053 0.109±0.00 N/A N/A 0.456±0.00 0.224±0.21

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00060U CIL_00060U_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005576 IDA extracellular region
GO:0005604 IEA basement membrane
GO:0005615 IDA extracellular space
GO:0007275 TAS multicellular organismal development
GO:0007568 IEA aging
GO:0007614 IEA short-term memory
GO:0008283 TAS cell proliferation
GO:0010447 IEA response to acidity
GO:0010596 IEA negative regulation of endothelial cell migration
GO:0010629 IEA negative regulation of gene expression
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0010976 IEA positive regulation of neuron projection development
GO:0016525 IDA negative regulation of angiogenesis
GO:0030162 IBA regulation of proteolysis
GO:0030424 IEA axon
GO:0031012 IDA extracellular matrix
GO:0042698 IEA ovulation cycle
GO:0043025 IEA neuronal cell body
GO:0043203 IEA axon hillock
GO:0046685 IEA response to arsenic-containing substance
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050728 IEA negative regulation of inflammatory response
GO:0050769 IDA positive regulation of neurogenesis
GO:0060041 IEA retina development in camera-type eye
GO:0060770 IEA negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 IDA extracellular vesicular exosome
GO:0071279 IEA cellular response to cobalt ion
GO:0071300 IEA cellular response to retinoic acid
GO:0071333 IEA cellular response to glucose stimulus
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:1901215 IEA negative regulation of neuron death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069048 serpinf1 protein_coding Danio_rerio
ENSMUSG00000000753 Serpinf1 protein_coding Mus_musculus

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