ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: FYVE, RhoGEF and PH domain containing 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139132 FGD4 9606 + 12:32399529-32646050 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000395740 FGD4-003 32502170-32638929 nonsense_mediated_decay
  ENST00000427716 FGD4-001 32502160-32646050 protein_coding
  ENST00000472289 FGD4-005 32502043-32582955 protein_coding
  ENST00000473513 FGD4-008 32502161-32579640 processed_transcript
  ENST00000479023 FGD4-009 32502179-32576344 processed_transcript
  ENST00000493087 FGD4-002 32502134-32640650 nonsense_mediated_decay
  ENST00000494275 FGD4-006 32502049-32582955 retained_intron
  ENST00000494977 FGD4-004 32582379-32644751 nonsense_mediated_decay
  ENST00000497153 FGD4-007 32502131-32576298 processed_transcript
  ENST00000525053 FGD4-011 32534324-32640737 protein_coding
  ENST00000531134 FGD4-010 32485972-32640739 protein_coding
  ENST00000534526 FGD4-013 32399529-32640533 protein_coding
  ENST00000546442 FGD4-015 32502184-32641519 protein_coding
  ENST00000550091 FGD4-016 32399856-32582251 processed_transcript
  ENST00000551984 FGD4-014 32502157-32640748 nonsense_mediated_decay
  ENST00000583694 FGD4-017 32502217-32576448 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHUVECENST00000427716ENST00000525053ENST00000531134ENST00000534526ENST00000546442ENST00000550091ENST00000551984
Transcript ID HAoEC HHSEC HUVEC
ENST00000427716 2.601±3.05 0.143±0.00 3.675±2.52
ENST00000525053 0.906±0.22 N/A 2.674±1.24
ENST00000531134 0.853±0.34 N/A N/A
ENST00000534526 1.348±1.06 N/A 1.617±0.91
ENST00000546442 0.882±0.00 N/A N/A
ENST00000550091 N/A N/A 0.148±0.00
ENST00000551984 1.012±0.10 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003DJ CIL_0003DJ_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0003779 IEA actin binding
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0015629 IDA actin cytoskeleton
GO:0030027 ISS lamellipodium
GO:0030032 IEA lamellipodium assembly
GO:0030035 IEA microspike assembly
GO:0030036 ISS actin cytoskeleton organization
GO:0030175 IEA filopodium
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060248 FGD4 (1 of 2) protein_coding Danio_rerio
ENSMUSG00000022788 Fgd4 protein_coding Mus_musculus

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