ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: tropomyosin 1 (alpha)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140416 TPM1 9606 + 15:63042632-63071915 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267996 TPM1-005 63042758-63071915 protein_coding
  ENST00000288398 TPM1-001 63042632-63066093 protein_coding
  ENST00000317516 TPM1-016 63048576-63069943 protein_coding
  ENST00000334895 TPM1-011 63048366-63070632 protein_coding
  ENST00000357980 TPM1-008 63042751-63071912 protein_coding
  ENST00000358278 TPM1-018 63042685-63071889 protein_coding
  ENST00000403994 TPM1-002 63042750-63066013 protein_coding
  ENST00000404484 TPM1-012 63048467-63071884 protein_coding
  ENST00000558072 TPM1-025 63062057-63071323 retained_intron
  ENST00000558264 TPM1-017 63055729-63071912 nonsense_mediated_decay
  ENST00000558314 TPM1-006 63042751-63061265 retained_intron
  ENST00000558347 TPM1-009 63042755-63071885 nonsense_mediated_decay
  ENST00000558400 TPM1-030 63056861-63059962 retained_intron
  ENST00000558544 TPM1-013 63048500-63071882 nonsense_mediated_decay
  ENST00000558868 TPM1-021 63048537-63061098 retained_intron
  ENST00000558910 TPM1-023 63062629-63065278 protein_coding
  ENST00000559108 TPM1-031 63062108-63066092 retained_intron
  ENST00000559281 TPM1-015 63048576-63066003 protein_coding
  ENST00000559397 TPM1-010 63042758-63071900 protein_coding
  ENST00000559556 TPM1-028 63042758-63071222 protein_coding
  ENST00000559831 TPM1-029 63044141-63062598 nonsense_mediated_decay
  ENST00000560131 TPM1-026 63063804-63066093 retained_intron
  ENST00000560445 TPM1-019 63042747-63066176 protein_coding
  ENST00000560615 TPM1-022 63048813-63062277 protein_coding
  ENST00000560679 TPM1-024 63054449-63059590 protein_coding
  ENST00000560959 TPM1-014 63048562-63062892 protein_coding
  ENST00000560970 TPM1-003 63042888-63066093 protein_coding
  ENST00000560975 TPM1-007 63042684-63071323 retained_intron
  ENST00000561242 TPM1-032 63061234-63062332 retained_intron
  ENST00000561266 TPM1-027 63043776-63064146 protein_coding
  ENST00000561395 TPM1-033 63057006-63066091 nonsense_mediated_decay
  ENST00000561425 TPM1-020 63042751-63057010 nonsense_mediated_decay
  ENST00000610733 TPM1-034 63042687-63047726 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000358278ENST00000404484ENST00000558314ENST00000558347ENST00000558544ENST00000559556ENST00000560975ENST00000610733
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000358278 127.476±0.00 61.578±27.99 N/A 120.671±0.00 173.694±98.07
ENST00000404484 N/A N/A 4.751±0.00 N/A 0.520±0.00
ENST00000558314 N/A N/A N/A N/A 69.801±0.00
ENST00000558347 79.523±12.94 72.435±30.78 N/A 84.021±0.00 94.291±0.00
ENST00000558544 45.147±0.00 N/A 3.295±0.00 N/A N/A
ENST00000559556 N/A N/A N/A N/A 95.126±0.00
ENST00000560975 N/A N/A N/A N/A 82.953±5.22
ENST00000610733 N/A N/A N/A N/A 22.408±3.88

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000502 CIL_000502_0002 CGP
CIL_00094O CIL_00094O_0001 VISTA
CIL_00098V CIL_00098V_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001725 IDA stress fiber
GO:0003065 ISS positive regulation of heart rate by epinephrine
GO:0003779 TAS actin binding
GO:0005200 TAS structural constituent of cytoskeleton
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 TAS cytoskeleton
GO:0005862 TAS muscle thin filament tropomyosin
GO:0006928 TAS cellular component movement
GO:0006936 TAS muscle contraction
GO:0006937 TAS regulation of muscle contraction
GO:0007010 TAS cytoskeleton organization
GO:0008016 TAS regulation of heart contraction
GO:0008092 IPI cytoskeletal protein binding
GO:0008307 TAS structural constituent of muscle
GO:0030016 IEA myofibril
GO:0030017 TAS sarcomere
GO:0030049 ISS muscle filament sliding
GO:0030336 ISS negative regulation of cell migration
GO:0031529 ISS ruffle organization
GO:0031941 IEA filamentous actin
GO:0032059 IMP bleb
GO:0032587 IDA ruffle membrane
GO:0032781 ISS positive regulation of ATPase activity
GO:0034614 IEP cellular response to reactive oxygen species
GO:0042060 ISS wound healing
GO:0045214 IMP sarcomere organization
GO:0045785 ISS positive regulation of cell adhesion
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0060048 IMP cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033683 tpma protein_coding Danio_rerio
ENSMUSG00000032366 Tpm1 protein_coding Mus_musculus

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