ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: promyelocytic leukemia
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140464 PML 9606 + 15:73994673-74047812 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268058 PML-001 73994717-74046771 protein_coding
  ENST00000268059 PML-003 73994717-74036394 protein_coding
  ENST00000354026 PML-004 73994717-74036394 protein_coding
  ENST00000359928 PML-013 73994744-74043338 protein_coding
  ENST00000395132 PML-002 73994717-74036394 protein_coding
  ENST00000395135 PML-006 73994673-74043337 protein_coding
  ENST00000435786 PML-010 73994744-74036394 protein_coding
  ENST00000436891 PML-011 73994744-74036394 protein_coding
  ENST00000562086 PML-018 74024880-74036394 protein_coding
  ENST00000563500 PML-015 73994803-74036393 protein_coding
  ENST00000564428 PML-012 73994744-74043338 protein_coding
  ENST00000564725 PML-016 73998024-74028442 retained_intron
  ENST00000565239 PML-022 74022912-74036122 protein_coding
  ENST00000565317 PML-021 74041329-74043342 processed_transcript
  ENST00000565898 PML-005 73994729-74047812 protein_coding
  ENST00000566068 PML-023 74023295-74035335 protein_coding
  ENST00000567543 PML-009 73994744-74034558 protein_coding
  ENST00000567606 PML-017 74022981-74036394 protein_coding
  ENST00000569161 PML-019 74022905-74032714 processed_transcript
  ENST00000569477 PML-007 73994731-74035590 protein_coding
  ENST00000569965 PML-008 73994733-74043338 protein_coding
  ENST00000570213 PML-020 74032395-74033205 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000268058ENST00000268059ENST00000354026ENST00000395132ENST00000395135ENST00000435786ENST00000562086ENST00000563500ENST00000564428ENST00000564725ENST00000565898ENST00000567543ENST00000567606ENST00000569477
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000268058 13.341±0.80 17.167±7.54 4.936±0.00 40.679±0.00 8.152±6.67
ENST00000268059 N/A 10.572±0.00 N/A N/A 12.415±9.58
ENST00000354026 N/A 14.683±0.89 N/A N/A 14.800±15.23
ENST00000395132 N/A N/A N/A N/A 13.068±0.00
ENST00000395135 N/A N/A N/A N/A 8.715±2.13
ENST00000435786 N/A N/A N/A N/A 3.205±1.79
ENST00000562086 N/A N/A 16.684±0.00 N/A 6.459±1.21
ENST00000563500 N/A N/A N/A N/A 0.528±0.10
ENST00000564428 17.469±0.00 16.093±6.72 N/A N/A 16.673±11.67
ENST00000564725 N/A 2.110±0.29 N/A N/A 1.898±1.28
ENST00000565898 7.425±0.00 0.693±0.00 3.057±0.00 10.771±0.00 1.189±1.17
ENST00000567543 N/A N/A N/A N/A 4.300±4.07
ENST00000567606 35.574±4.65 25.147±2.11 25.905±0.00 N/A N/A
ENST00000569477 N/A N/A N/A N/A 0.104±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0001932 ISS regulation of protein phosphorylation
GO:0002230 IMP positive regulation of defense response to virus by host
GO:0003677 IEA DNA binding
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005829 ISS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006461 IDA protein complex assembly
GO:0006605 IDA protein targeting
GO:0006915 IDA apoptotic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 ISS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IDA cell cycle arrest
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007182 IEA common-partner SMAD protein phosphorylation
GO:0007184 IEA SMAD protein import into nucleus
GO:0007569 IEA cell aging
GO:0008270 IEA zinc ion binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 IEA response to UV
GO:0010332 IEA response to gamma radiation
GO:0010522 ISS regulation of calcium ion transport into cytosol
GO:0016032 IEA viral process
GO:0016363 IDA nuclear matrix
GO:0016525 IMP negative regulation of angiogenesis
GO:0016605 IDA PML body
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030099 IEA myeloid cell differentiation
GO:0030308 IDA negative regulation of cell growth
GO:0030578 IDA PML body organization
GO:0031065 IDA positive regulation of histone deacetylation
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031965 IDA nuclear membrane
GO:0032183 IPI SUMO binding
GO:0032211 IMP negative regulation of telomere maintenance via telomerase
GO:0032469 ISS endoplasmic reticulum calcium ion homeostasis
GO:0032922 ISS circadian regulation of gene expression
GO:0032938 IDA negative regulation of translation in response to oxidative stress
GO:0034097 IDA response to cytokine
GO:0042406 ISS extrinsic component of endoplasmic reticulum membrane
GO:0042752 ISS regulation of circadian rhythm
GO:0042771 ISS intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 IPI protein homodimerization activity
GO:0043153 ISS entrainment of circadian clock by photoperiod
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 IDA innate immune response
GO:0045165 IEA cell fate commitment
GO:0045343 IEA regulation of MHC class I biosynthetic process
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0046332 IEA SMAD binding
GO:0046982 IDA protein heterodimerization activity
GO:0048384 IEA retinoic acid receptor signaling pathway
GO:0050821 IDA protein stabilization
GO:0050897 IDA cobalt ion binding
GO:0051457 IDA maintenance of protein location in nucleus
GO:0051607 IEA defense response to virus
GO:0051974 IMP negative regulation of telomerase activity
GO:0060058 IDA positive regulation of apoptotic process involved in mammary gland involution
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060444 IEA branching involved in mammary gland duct morphogenesis
GO:0070059 IEA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353 IEA cellular response to interleukin-4
GO:0072332 IEA intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090398 IDA cellular senescence
GO:0097191 IEA extrinsic apoptotic signaling pathway
GO:1902187 IDA negative regulation of viral release from host cell
GO:2000059 IMP negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000779 IMP regulation of double-strand break repair
GO:2001235 IEA positive regulation of apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000036986 Pml protein_coding Mus_musculus

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